Synergistic hypotensive effect of vasoactive intestinal polypeptide and alpha-blockade with phentolamine. Evidence for vasoactive intestinal peptide alpha-adrenoceptor coupling in the cardiovascular system of newborn dogs.
血管活性肠多肽的协同降压作用和酚妥拉明的 α 阻滞作用。新生犬心血管系统中血管活性肠肽 α-肾上腺素受体偶联的证据。

摘要

Vasoactive intestinal polypeptide (VIP) is a neuropeptide with potent circulatory effects in the adult animal and human. Little is known about its effects or mechanism of action in the immature animal. These series of experiments evaluated the effects and possible mechanism of action of VIP on the developing canine cardiovascular system. In all three series, measurements of mean heart rate and blood pressure were taken in the control state, after parasympathetic denervation with bilateral cervical vagotomies, and after autonomic blockade with propranolol (1 mg/kg) and phentolamine (0.5 mg i.v.). In series 1, we characterized the role of alpha-adrenergic receptors in early newborn puppies by investigating the hemodynamic effects of phentolamine alone in five early newborn puppies. In series 2, the hemodynamic effects of intravenous VIP infusion (0.2 microgram/kg/min) were recorded and compared in six early newborn puppies and in 10 late newborn puppies. In series 3, the hemodynamic effects of phentolamine in the presence of VIP receptor binding inhibitor were studied. In early newborn puppies, VIP had essentially no effect on heart rate or blood pressure until phentolamine was given; then, blood pressure decreased by 17% (p less than 0.005). In late newborn puppies, VIP resulted in an increase in heart rate in the control state but not after parasympathetic or sympathetic denervation. In early newborn puppies, phentolamine alone resulted in a 24% decrease (p less than 0.005) in blood pressure, compared with a 54% decrease (p less than 0.005) in early newborn puppies preexposed to VIP infusion.(ABSTRACT TRUNCATED AT 250 WORDS)

译文

血管活性肠多肽 (VIP) 是一种在成年动物和人类体内具有强大循环作用的神经肽。对其在未成熟动物中的作用或作用机制知之甚少。这些系列实验评估了 VIP 对发展中的犬心血管系统的影响和可能的作用机制。在所有三个系列中,平均心率和血压的测量是在对照状态下进行的,在双侧宫颈迷走神经切断后,在心得安 (1 毫克/千克) 自主神经阻滞后进行的和酚妥拉明 (0.5 毫克 i。 v.)。在系列 1 中,我们通过研究酚妥拉明单独在 5 只早期新生幼犬中的血流动力学效应,描述了 α-肾上腺素能受体在早期新生幼犬中的作用。在系列 2 中,记录并比较了静脉注射 VIP (0.2 微克/千克/分钟) 对 6 只早期新生幼犬和 10 只晚期新生幼犬的血流动力学影响。在系列 3 中,研究了在 VIP 受体结合抑制剂存在下酚妥拉明的血流动力学效应。在早期新生幼犬中,在给予酚妥拉明之前,VIP 对心率或血压基本没有影响; 然后,血压下降了 17% (p 小于 0.005)。在晚期新生幼犬中,VIP 导致在控制状态下的心率增加,但在副交感神经或交感神经去神经支配后没有。在早期新生幼犬中,酚妥拉明单独导致血压下降 24% (p 低于 0.005),而血压下降 54% (p 低于 0.005) 在暴露于 VIP 输注的早期新生小狗中。 (摘要删减为 250 字)

phentolamine

心血管 短效的非选择性α受体阻滞剂 药物
概述  :  

药理作用短效的非选择性α受体阻滞剂,对α1、α2受体均有作用,能拮抗血液循环中肾上腺素和去甲肾上腺素的作用,使血管扩张而降低周围血管阻力;拮抗儿茶酚胺效应,用于诊治嗜铬细胞瘤,但对正常人或原发性高血压患者的血压影响甚少;能降低外周血管阻力,使心脏后负荷降低,左心室舒张末压和肺动脉压下降,心搏出量增加,可用于治疗心力衰竭。适应证1、预防和治疗嗜铬细胞瘤所致的高血压发作,包括手术切除时出现的阵发性高血压,也用于协助诊断嗜铬细胞瘤。2、预防和治疗因去甲肾上腺素静脉给药外溢而引起的皮肤坏死。3、心力衰竭

phentolamine  [fen'tɒləmiːn]  

释义   n. 酚妥拉明,芬妥胺(一种肾上腺素阻滞剂)

例句   Objective: To observe the effectiveness of Phentolamine and Dobutamine treating Chronic Pulmonary heart with the serious heart failure.  目的:观察酚妥拉明与多巴酚丁胺合用对肺心病合并严重心衰的治疗效果。


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