摘要

Lung cancer risk and tumor characteristics differ between sexes. Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men. This was a nationwide Swedish population-based cohort study between July 1, 2005 and December 31, 2013. Data on the use of digitalis and organic nitrates in all male individuals were derived from the Swedish Prescribed Drug Registry. New lung cancer diagnoses among cohort participants were identified from the Swedish Cancer Registry. Cox proportional hazards regression was employed to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) of lung cancer in digitalis users (exposed participants) compared to users of organic nitrates without digitalis medication (unexposed participants). The study cohort contained 74,437 digitalis users and 297,301 organic nitrates users. Long-term use (≥2 years) of digitalis was associated with decreased HRs of total lung cancer (HR 0.55, 95% CI 0.39-0.79) and squamous cell carcinoma (HR 0.40, 95% CI 0.19-0.87). This large and population-based study suggests decreased risks of lung cancer overall and squamous cell carcinoma associated with long-term use of digitalis in men.

译文

肺癌风险和肿瘤特征之间的差异。雌激素有人抵制肺癌。我们的目的是测试假设洋地黄类药物的使用减少患肺癌的危险由于雌激素和抗癌特性的男人。这是一个全国 2013年12月31日 2005年7月1日之间的瑞典人的队列研究。关于使用洋地黄类和有机硝酸盐在所有的个人是来自瑞典的处方药品登记册。新的肺癌诊断癌症登记与会者确定了瑞典的队列中。回归 Cox 比例风险隐患进行了博弈均衡比例 (小时) 的 95% 可信区间 (CIs) 肺癌洋地黄类药物使用者 (使与会者) 而用户的有机硝酸酯无洋地黄类药物 (未用完的人)。队列研究中包含 74,437 洋地黄类药物使用者和 297,301 有机硝酸盐的用户。长期使用 (≥ 月年) 的洋地黄类药物与减小时的肺癌 (HR 0.55，95% CI 0.39 ~ 0.79) 和鳞状细胞癌 (HR 0.40, 95% CI 0.19 ~ 0.87)。这个大，以人口为基础的肺癌的综合研究表明，减少风险和鳞状细胞癌与长期使用洋地黄的男人。