摘要

Lung cancer risk and tumor characteristics differ between sexes. Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men. This was a nationwide Swedish population-based cohort study between July 1, 2005 and December 31, 2013. Data on the use of digitalis and organic nitrates in all male individuals were derived from the Swedish Prescribed Drug Registry. New lung cancer diagnoses among cohort participants were identified from the Swedish Cancer Registry. Cox proportional hazards regression was employed to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) of lung cancer in digitalis users (exposed participants) compared to users of organic nitrates without digitalis medication (unexposed participants). The study cohort contained 74,437 digitalis users and 297,301 organic nitrates users. Long-term use (≥2 years) of digitalis was associated with decreased HRs of total lung cancer (HR 0.55, 95% CI 0.39-0.79) and squamous cell carcinoma (HR 0.40, 95% CI 0.19-0.87). This large and population-based study suggests decreased risks of lung cancer overall and squamous cell carcinoma associated with long-term use of digitalis in men.

译文

肺癌风险和肿瘤特征之间的差异。雌激素有人抵制肺癌。我们的目的是测试假设洋地黄类药物的使用减少患肺癌的危险由于雌激素和抗癌特性的男人。这是一个全国 2013年12月31日 2005年7月1日之间的瑞典人的队列研究。关于使用洋地黄类和有机硝酸盐在所有的个人是来自瑞典的处方药品登记册。新的肺癌诊断癌症登记与会者确定了瑞典的队列中。回归 Cox 比例风险隐患进行了博弈均衡比例 (小时) 的 95% 可信区间 (CIs) 肺癌洋地黄类药物使用者 (使与会者) 而用户的有机硝酸酯无洋地黄类药物 (未用完的人)。队列研究中包含 74,437 洋地黄类药物使用者和 297,301 有机硝酸盐的用户。长期使用 (≥ 月年) 的洋地黄类药物与减小时的肺癌 (HR 0.55,95% CI 0.39 ~ 0.79) 和鳞状细胞癌 (HR 0.40, 95% CI 0.19 ~ 0.87)。这个大,以人口为基础的肺癌的综合研究表明,减少风险和鳞状细胞癌与长期使用洋地黄的男人。

Digitalis

心血管 治疗心衰非常有效的药物 药物
概述  :  

适应症1、伴有快速心房颤动/心房扑动的收缩性心力衰竭是应用洋地黄的最佳指征,同时也包括扩张型心肌病、二尖瓣或主动脉瓣病变、陈旧性心肌梗死及高血压心脏病所致慢性心力衰竭。2、在利尿剂、ACEI/ARB和β受体拮抗剂治疗过程中仍持续有心衰症状的患者可考虑加用地高辛。禁忌症1、高排量心衰禁用:如贫血性心脏病、甲状腺功能亢进以及心肌炎、心肌病等所致心衰。2、肺源性心脏病合并心肌梗死、缺血性心肌病时,易发生洋地黄中毒,应慎用。3、肥厚型心肌病:洋地黄可增加心肌收缩性,可能使原有的血流动力学障碍更为加重。4

digitalis 英[ˌdɪdʒɪˈteɪlɪs]

释义   n.黄地黄;毛地黄

例句   We are lack of an uniform index diagnosis of digitalis intoxication. 我们缺乏统一的洋地黄中毒的诊断标准。


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