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pyroptosis

心血管

关键词心血管 临床研究术语 程序性死亡

词汇介绍

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解析

pyroptosis

释义   细胞焦亡

例句   Three such regulated necrotic cell death modalities in macrophages contribute to different pathologies, including necroptosis, pyroptosis, and parthanatos.
巨噬细胞中三种受调节的坏死性细胞死亡模式导致了不同的病理,包括坏死性凋亡、焦亡和依赖性死亡。

概述

当宿主受到外源性和内源性等病原微生物的攻击时,细胞可通过程序性死亡方式以清除受感染的细胞。病原体诱导宿主细胞死亡的特殊性方式有细胞凋亡和细胞坏死等。近年来,随着国内外相关研究的进一步开展,已发现细胞胀亡( oncosis) 、细胞焦亡( pyroptosis)、自噬等新的细胞死亡方式。细胞焦亡是一种胱天蛋白酶( caspase) 依赖的细胞促炎程序性死亡方式,伴有大量炎性因子的释放。细胞凋亡和细胞焦亡都是由 caspase 介导的。细胞凋亡由凋亡性 caspase 介导, 它们包括 casp

Programmed necrotic cell death of macrophages: Focus on pyroptosis,necroptosis, and parthanatos复制标题

巨噬细胞的程序性坏死细胞死亡: 聚焦于焦斑病、坏死性囊肿病和帕金森病

发表时间:2019-09-10

影响因子:7.8

作者: Nirmal Robinson

期刊:Redox Biol

Macrophages are highly plastic cells of the innate immune system. Macrophages play central roles in immunity against microbes and contribute to a wide array of pathologies. The processes of macrophage activation and their functions have attracted considerable attention from life scientists. Although macrophages are highly resistant to many toxic stimuli, including oxidative stress, macrophage death has been reported in certain diseases, such as viral infections, tuberculosis, atherosclerotic plaque development, inflammation, and sepsis. While most studies on macrophage death focused on apoptosis, a significant body of data indicates that programmed necrotic cell death forms may be equally important modes of macrophage death. Three such regulated necrotic cell death modalities in macrophages contribute to different pathologies, including necroptosis, pyroptosis, and parthanatos. Various reactive oxygen and nitrogen species, such as superoxide, hydrogen peroxide, and peroxynitrite have been shown to act as triggers, mediators, or modulators in regulated necrotic cell death pathways. Here we discuss recent advances in necroptosis, pyroptosis, and parthanatos, with a strong focus on the role of redox homeostasis in the regulation of these events.

译文

巨噬细胞是先天免疫系统的高度可塑性细胞。巨噬细胞在抵抗微生物的免疫中起着核心作用,并导致多种病理。巨噬细胞的活化过程及其功能引起了生命科学家的极大关注。尽管巨噬细胞对包括氧化应激在内的许多毒性刺激具有很高的抵抗力,但据报道在某些疾病中巨噬细胞死亡,例如病毒感染,结核病,动脉粥样硬化斑块发展,炎症和败血症。虽然大多数有关巨噬细胞死亡的研究都集中在凋亡,但大量数据表明,程序性坏死细胞死亡形式可能是巨噬细胞死亡的同等重要方式。巨噬细胞中三种受调节的坏死性细胞死亡模式导致了不同的病理,包括坏死性坏死病,发烧性坏死病和parthanatos。各种活性氧和氮物种(例如超氧化物,过氧化氢和过氧亚硝酸盐)已显示出在受控坏死细胞死亡途径中的触发剂,介体或调节剂。在这里,我们讨论了坏死病,发烧病和单性结节病的最新进展,重点关注氧化还原稳态在这些事件的调节中的作用。