The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection.
焦下垂在胃肠道癌症和肠道微生物感染免疫反应中的作用。
Colitis-associated colorectal cancer Gastric cancer Gut microbiota Mucosal innate immune response Pyroptosis
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摘要

Pyroptosis, a type of inflammatory programmed cell death, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β2. It can induce cancer cell death within the gastrointestinal tract. NLRs3, AIM24, GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, etc. Furthermore, several inflammasomes are elucidated to be involved in mucosal innate immune responses and modulate specific enteric pathogens infection. Precise modulation of inflammasome activation and exploration of potential diagnostic markers can contribute to the diagnosis, prevention and treatment of intestinal tumors and inflammatory or infectious disorders in human patients in the near future.

译文

焦亡是一种炎性程序性细胞死亡,由多个炎性体介导,这些炎性体可以识别危险信号并激活促炎细胞因子如 IL-181 和 IL-1 β 2 的分泌。它可以诱导胃肠道内的癌细胞死亡。NLRs3 、 AIM24 、 GSDM5 家族在胃癌、结肠炎相关结直肠癌和食道癌等肠癌的焦亡信号通路中发挥重要作用。此外,几个炎症小体被阐明参与粘膜先天免疫反应并调节特异性肠道病原体感染。炎症小体激活的精确调节和潜在诊断标记物的探索有助于在不久的将来诊断、预防和治疗人类患者的肠道肿瘤和炎症或感染性疾病。

pyroptosis

心血管 程序性死亡 临床研究术语
概述  :  

当宿主受到外源性和内源性等病原微生物的攻击时,细胞可通过程序性死亡方式以清除受感染的细胞。病原体诱导宿主细胞死亡的特殊性方式有细胞凋亡和细胞坏死等。近年来,随着国内外相关研究的进一步开展,已发现细胞胀亡( oncosis) 、细胞焦亡( pyroptosis)、自噬等新的细胞死亡方式。细胞焦亡是一种胱天蛋白酶( caspase) 依赖的细胞促炎程序性死亡方式,伴有大量炎性因子的释放。细胞凋亡和细胞焦亡都是由 caspase 介导的。细胞凋亡由凋亡性 caspase 介导, 它们包括 casp

pyroptosis

释义   细胞焦亡

例句   Three such regulated necrotic cell death modalities in macrophages contribute to different pathologies, including necroptosis, pyroptosis, and parthanatos.
巨噬细胞中三种受调节的坏死性细胞死亡模式导致了不同的病理,包括坏死性凋亡、焦亡和依赖性死亡。

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