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首页 > 医学词汇大全 > Hydrochlorothiazide
Hydrochlorothiazide

心血管

关键词心血管 药物 原发性高血压

词汇介绍

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解析

Hydrochlorothiazide 英 ['haɪdrəʊ,klɔːrə'θaɪəzaɪd] 

释义   n. [药] 氢氯噻嗪;二氢氯噻;双氢克尿噻

例句   To establish a RP-HPLC method for determination of the content ofhydrochlorothiazide tablets. 

建立以反相高效液相色谱法测定氢氯噻嗪片含量的方法。


概述

适应证氢氯噻嗪治疗高血压,可单独服用,或与其他降压药联合应用,主要用于治疗原发性高血压。药代动力学口服吸收迅速,但不完全。进入体内后分布于各组织,以肾脏含量最高。肝脏次之。一般口服lh后产生利尿作用,约2h后血药浓度达峰值,维持12-18h。t1/2约为12h。服用量的95%以原形从近曲小管分泌,由尿排出。作用与用途此药可抑制肾脏髓襻升支对Cl-的主动重吸收,从而使水、Na+的重吸收减少,Na+、K+、Cl-的排出增加。用于多种原因引起的水肿、尿崩症及高血压的辅助治疗;还可减少Ca2+的排出,用

Polypill for Cardiovascular Disease Prevention in an Underserved Population复制标题

在服务不足的人群中预防心血管疾病的息肉

发表时间:2019-09-19

影响因子:70.7

作者: Daniel Muñoz

期刊:N. Engl. J. Med.

Persons with low socioeconomic status and nonwhite persons in the United States have high rates of cardiovascular disease. The use of combination pills (also called “polypills”) containing low doses of medications with proven benefits for the prevention of cardiovascular disease may be beneficial in such persons. However, few data are available regarding the use of polypill therapy in underserved communities in the United States, in which adherence to guideline-based care is generally low.We conducted a randomized, controlled trial involving adults without cardiovascular disease. Participants were assigned to the polypill group or the usual-care group at a federally qualified community health center in Alabama. Components of the polypill were atorvastatin (at a dose of 10 mg), amlodipine (2.5 mg), losartan (25 mg), and hydrochlorothiazide (12.5 mg). The two primary outcomes were the changes from baseline in systolic blood pressure and low-density lipoprotein (LDL) cholesterol level at 12 months.

译文

在美国,社会经济地位低下的人和非白人具有较高的心血管疾病发病率。使用含有低剂量药物且已证明具有预防心血管疾病益处的组合药(也称为“多药”)可能对此类人有益。但是,在美国服务欠缺的社区中,关于使用多药治疗的数据很少,在这些社区中,对基于指南的护理的依从性普遍较低。我们进行了一项随机对照试验,涉及没有心血管疾病的成年人。在阿拉巴马州的联邦合格社区卫生中心,将参与者分配到息肉药组或常规护理组。多药的成分是阿托伐他汀(剂量为10毫克),氨氯地平(2.5毫克),氯沙坦(25毫克)和氢氯噻嗪(12.5毫克)。这两个主要结局是12个月时收缩压和低密度脂蛋白(LDL)胆固醇水平相对于基线的变化。