Creatine 英 ['kriːətiːn] 美 ['kriə,tɪn]
释义 n. 肌（氨）酸，肌肉素
短语 creatine kinase 肌酸激酶
creatine phosphokinase 肌酸磷酸激酶
例句 To study the expression of mitochondrial creatine kinase in lung cancers.
Kinase 英 [ˈkaɪneɪz] 美 [ˈkɪnneɪz]
释义 n. [生化] 激酶；致活酶
短语 protein kinase 蛋白激酶
thymidine kinase 胸苷激酶；胸腺嘧啶核苷漱酶
例句 More than 500 kinases have been identified, but we only have a half-dozen targeted kinase inhibitors.
Isoenzyme 英 ['aɪsəʊ,enzaɪm] 美 [,aɪso'ɛn,zaɪm]
释义 n. [生化] 同工酶；同功酶
例句 After reperfusion, the serum levels of MB isoenzyme of creatine kinase and lactate dehydrogenase were measured with automatic biochemical analyzer.
作者： Emilie P. Belley-Cote
期刊：Eur J Cardiothorac Surg
The universal definitions for myocardial infarction (MI) after coronary artery bypass grafting (CABG) surgery are based on a cardiac biomarker elevation >10 times the 99th percentile concentration (designated as the upper limit of normal; ULN) from a healthy population. These post-CABG MI diagnostic criteria are based on an arbitrary biomarker elevation threshold in association with signs of cardiac necrosis. In 2012, the Task Force elected to increase the biomarker elevation threshold for the Third Universal definition because the initial >5xULN threshold was considered too sensitive. In 2013, the Society for Cardiovascular Angiography and Interventions suggested another definition using different biomarker elevation thresholds depending on whether new pathological Q waves or left bundle branch block (LBBB) was present. These different MI definitions have never undergone rigorous validation in the context of CABG to assess their association with clinically important events. They were also established when creatine kinase (CK)-MB was the biomarker of choice to diagnose post-CABG MI. In many centres, cardiac troponins have replaced CK-MB. Given the ubiquitous release of cardiac troponin during CABG surgery, the prognostic value of using a 10-fold ULN threshold has been questioned by clinicians when diagnosing post-CABG MI. Therefore, we aimed to identify a prognostically relevant cardiac troponin threshold post-CABG MI.