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首页 > 医学词汇大全 > creatine kinase isoenzyme
creatine kinase isoenzyme

心血管

关键词心血管 临床研究术语 CK

词汇介绍

拓展阅读

解析

Creatine 英 ['kriːətiːn]  美 ['kriə,tɪn] 

释义   n. 肌(氨)酸,肌肉素

短语   creatine kinase 肌酸激酶

creatine phosphokinase 肌酸磷酸激酶

例句   To study the expression of mitochondrial creatine kinase in lung cancers. 

研究线粒体肌酸激酶在肺癌中的表达及意义。

 

Kinase 英 [ˈkaɪneɪz]  美 [ˈkɪnneɪz] 

释义   n. [生化] 激酶;致活酶

短语   protein kinase 蛋白激酶

thymidine kinase 胸苷激酶;胸腺嘧啶核苷漱酶

例句   More than 500 kinases have been identified, but we only have a half-dozen targeted kinase inhibitors. 

现在已经发现了500多种激酶,但是我们只研制出六个靶向激酶抑制剂。

 

Isoenzyme 英 ['aɪsəʊ,enzaɪm]  美 [,aɪso'ɛn,zaɪm] 

释义   n. [生化] 同工酶;同功酶

例句   After reperfusion, the serum levels of MB isoenzyme of creatine kinase and lactate dehydrogenase were measured with automatic biochemical analyzer. 

再灌注结束后大鼠血清肌酸激酶同工酶、乳酸脱氢酶水平采用全自动生化仪检测。


概述

肌酸激酶(CK)分子是由两个亚单位组成的二聚体,每个亚单位的分子质量约40000 Da。脑型亚单位(B)及肌型亚单位(M)是两个不同结构基因的产物,形成二聚体时有活性,可产生3种CK同工酶(creatine kinase isoenzyme),即CK-BB(CK-1)、CK-MB(CK-2)及CK-MM(CK-3)。CK同工酶亚型测定主要是指后两者的检测。刚从组织中释放的CK-MB和CK-MM分别为CK-MB2和CK-MM3,称为组织亚型或基因型同工酶。CK-MB主要存在于心肌组织

Definitions of post-coronary artery bypass grafting myocardial infarction: variations in incidence and prognostic significance复制标题

冠状动脉旁路移植术后心肌梗死的定义: 发生率和预后意义的变化

发表时间:2019-06-10

影响因子:3.8

作者: Emilie P. Belley-Cote

期刊:Eur J Cardiothorac Surg

The universal definitions for myocardial infarction (MI) after coronary artery bypass grafting (CABG) surgery are based on a cardiac biomarker elevation >10 times the 99th percentile concentration (designated as the upper limit of normal; ULN) from a healthy population. These post-CABG MI diagnostic criteria are based on an arbitrary biomarker elevation threshold in association with signs of cardiac necrosis. In 2012, the Task Force elected to increase the biomarker elevation threshold for the Third Universal definition because the initial >5xULN threshold was considered too sensitive. In 2013, the Society for Cardiovascular Angiography and Interventions suggested another definition using different biomarker elevation thresholds depending on whether new pathological Q waves or left bundle branch block (LBBB) was present. These different MI definitions have never undergone rigorous validation in the context of CABG to assess their association with clinically important events. They were also established when creatine kinase (CK)-MB was the biomarker of choice to diagnose post-CABG MI. In many centres, cardiac troponins have replaced CK-MB. Given the ubiquitous release of cardiac troponin during CABG surgery, the prognostic value of using a 10-fold ULN threshold has been questioned by clinicians when diagnosing post-CABG MI. Therefore, we aimed to identify a prognostically relevant cardiac troponin threshold post-CABG MI.

译文

冠状动脉搭桥术(CABG)术后心肌梗死(MI)的通用定义是基于心脏生物标志物升高>健康人群中99%百分含量(指定为正常上限; ULN)的10倍。这些CABG MI后的诊断标准基于与心脏坏死征兆相关的任意生物标志物升高阈值。在2012年,工作组选择增加“第三通用”定义的生物标志物升高阈值,因为最初的> 5xULN阈值被认为过于敏感。 2013年,心血管血管造影和介入学会提出了另一种定义,即根据是否存在新的病理Q波或左束支传导阻滞(LBBB),使用不同的生物标志物升高阈值。在CABG的背景下,从未对这些不同的MI定义进行严格的验证,以评估它们与临床重要事件的关联。当肌酸激酶(CK)-MB是诊断CABG MI后的生物标志物时,也建立了它们。在许多中心,心肌肌钙蛋白已取代CK-MB。鉴于CABG手术期间心脏肌钙蛋白的普遍释放,临床医生在诊断CABG后MI时使用10倍ULN阈值的预后价值受到质疑。因此,我们旨在确定CABG MI后与预后相关的心肌肌钙蛋白阈值。