首页 > 心血管医学词汇大全 > persistent truncus arteriosus
Reduced L-type calcium current in the embryonic chick heart with persistent truncus arteriosus.
具有永存动脉干的胚胎鸡心中的 L 型钙电流减少。

摘要

Calcium currents were examined in an experimental model in the embryonic chick heart with a congenital malformation known as persistent truncus arteriosus. This is a severe defect characterized by failure of conotruncal and aorticopulmonary septation of the embryonic heart tube. As a result, no separation into the aortic and pulmonary arteries occurs, and there is a common outflow tract. The hearts with persistent truncus arteriosus had a 26% greater ventricular to whole embryo weight, which indicated that the ventricles were enlarged. Both the low-threshold T-type (ICa.T) and the 1,4-dihydropyridine-sensitive L-type (ICa.L) Ca2+ currents were present in the ventricular myocytes from hearts at day 11 of incubation. However, day 11 hearts with persistent truncus arteriosus showed a twofold reduction in the peak magnitude of ICa.L at a test potential of + 10 mV without a concomitant reduction in the number of L channels detected by 1,4-dihydropyridine antagonist [(+)[3H]PN200-110] and agonist (Bay K 8644) receptor binding. The results indicated that an L channel regulatory mechanism other than protein synthesis was affected. These changes are consistent with responses to conditions of excessive hemodynamic burden that have been characterized in adult hearts.

译文

在胚胎鸡心的实验模型中检测钙电流,鸡心具有先天性畸形,称为持续动脉干。这是一种严重的缺陷,其特征是胚胎心脏管的圆锥动脉干和主肺动脉分离失败。结果,主动脉和肺动脉没有分离,并且有一个共同的流出道。动脉干持续存在的心脏心室比整个胚胎重量大 26%,这表明心室增大了。低阈值 T 型 (ICa。 t) 和对 1,4-二氢吡啶敏感的 L 型 (ICa。 l) 培养天,来自心脏的心室肌细胞中存在 Ca2 电流。然而,第 11 天,具有持续性动脉干的心脏显示出 ICa 峰值的两倍减少。 L 在测试电位为 10毫伏时,1,4-二氢吡啶拮抗剂 [() [3 H] PN200-110] 和激动剂 (Bay K 8644) 检测到的 L 通道数量没有伴随减少受体结合。结果表明,除了蛋白质合成之外,L 通道调节机制也受到影响。这些变化与成人心脏对过度血流动力学负担的反应是一致的。

persistent truncus arteriosus

心血管 先天性心脏畸形 疾病
概述  :  

永存动脉干是原始动脉干在分隔发育过程中早期停顿,以致保存了胚胎期从心底部发出的单大动脉直接供应体循环、肺循环和冠状循环血流的一种非常少见的先天性心脏畸形,占先天性心脏病发病率的0.5%~3%。永存动脉干又名共同动脉干,仅有一组半月瓣,常合并动脉干下室间隔缺损。从心室底部发出的单一大动脉除永存动脉干外,还有假性主动脉干(肺动脉闭锁)和假性肺动脉干(主动脉闭锁),后两种假性动脉干又称为孤立性主动脉干(solitary aortic trunk)或孤立性肺动脉干(solitary pulmonar

Persistent 英 [pəˈsɪstənt]  美 [pərˈsɪstənt] 

释    义   adj. 执着的,坚持不懈的;持续的,反复出现的;(动植物某部位,如角、叶等)存留的,不落的

短    语   persistent data 不变数据;持久性数据

persistent infection 持续感染;持续性感染

同根词   词根  persist

adv. persistently 坚持地;固执地

n. perseverance 坚持不懈;不屈不挠  persistence 持续;固执;存留

例    句   So persistent, I love him so. 

如此执着的我,如此的爱他。

 

Truncus ['trʌŋkəs] 

释    义   n. [解剖] 躯干

例    句   AIM: To analyze structure of persistent truncus arteriosus (PTA), hemodynamics, and exploreselection of view. 

目的:分析永存动脉干(PTA)结构、血流动力学特征,并探讨切面的选择。

 

Arteriosus

释    义   adj. 动脉的

例    句   Most babies have a closed ductus arteriosus by 72 hours after birth. 

大多数婴儿在出生后72小时内动脉导管闭合。


请扫描右侧二维码,免费查看词汇专业知识背景