Troponin 英 /'trɔpənin, 'trəu-/ 美 /'trɔpənin, 'trəu-/
释义 n. 肌钙蛋白
例句 To explore change of serum troponin I(cTnI) in hemodialysis patients with chronic renal failure.
作者： Anupom Mondal
Electron microscopic studies showed that the TnT molecule has an extended conformation . High-resolution X-ray crystallographic structures have been obtained for the core region of human cardiac troponin complex and chicken fast skeletal muscle troponin complex . These solved high-resolution structures of the troponin complex contained entire TnC and most regions of TnI, but only a small C-terminal portion of TnT. The data showed that TnT interfaces with TnI in a coiled-coil structure (i.e., the I-T arm) formed by the segments of L224 -V274 of cardiac TnT and F90 -R136 of cardiac TnI in human cardiac troponin or E199-Q245 of fast TnT and G55-L102 of fast TnI in chicken fast skeletal muscle troponin. The C-terminal portion of the I-T arm also interacts with TnC. The observation that the N-terminal and the middle region as well as the very C-terminal end of TnT were not resolved in the high resolution crystallographic structures implicates a flexibility of these regions, likely reflecting their allosteric functions in the troponin regulation of muscle contraction.