摘要

BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased morbidity and mortality, and decreased quality of life. Treatment with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs) is effective for many symptoms of OSA. However, it remains controversial whether treatment with CPAP or MAD also improves depressive symptoms. METHODS AND FINDINGS: We performed a systematic review and meta-analysis of randomized controlled trials that examined the effect of CPAP or MADs on depressive symptoms in patients with OSA. We searched Medline, EMBASE, the Cochrane Central Registry of Controlled Trials, and PsycINFO from the inception of the databases until August 15, 2014, for relevant articles. In a random effects meta-analysis of 19 identified trials, CPAP treatment resulted in an improvement in depressive symptoms compared to control, but with significant heterogeneity between trials (Q statistic, p

译文

背景: 阻塞性睡眠呼吸暂停 (OSA) 与发病率和死亡率的增加以及生活质量的下降有关。持续气道正压通气 (CPAP) 或下颌前移装置 (MADs) 治疗 OSA 的许多症状是有效的。然而，CPAP 或 MAD 治疗是否也能改善抑郁症状仍有争议。方法和结果: 我们对随机对照试验进行了系统回顾和荟萃分析，这些试验检测了 CPAP 或 MADs 对 OSA 患者抑郁症状的影响。从数据库建立到 2014年8月15日，我们检索了 Medline 、 EMBASE 、 Cochrane 中心对照试验注册中心和 PsycINFO 的相关文章。在 19 个确定试验的随机效应荟萃分析中，与对照组相比，CPAP 治疗导致了抑郁症状的改善，但是在试验之间具有显著的异质性 (Q 统计，p