摘要

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients, but not without side effects. We have demonstrated that glycine preserves muscle in various wasting models. Since glycine effectively suppresses the activity of pro-inflammatory macrophages, we investigated the potential of glycine treatment to ameliorate the dystrophic pathology. Dystrophic mdx and dystrophin-utrophin null (dko) mice were treated with glycine or L-alanine (amino acid control) for up to 15 weeks and voluntary running distance (a quality of life marker and strong correlate of lifespan in dko mice) and muscle morphology were assessed. Glycine increased voluntary running distance in mdx mice by 90% (P < 0.05) after 2 weeks and by 60% (P < 0.01) in dko mice co-treated with prednisolone over an 8 week treatment period. Glycine treatment attenuated fibrotic deposition in the diaphragm by 28% (P < 0.05) after 10 weeks in mdx mice and by 22% (P < 0.02) after 14 weeks in dko mice.

译文

杜氏肌营养不良症(DMD)是一种X连锁遗传疾病,其特征在于进行性肌肉萎缩,虚弱和过早死亡。糖皮质激素(例如泼尼松龙)仍是唯一对DMD患者具有有利影响的药物,但并非没有副作用。我们已经证明甘氨酸可以在各种消耗模型中保留肌肉。由于甘氨酸有效抑制促炎巨噬细胞的活性,我们研究了甘氨酸治疗改善营养不良病理的潜力。营养不良mdx和肌营养不良蛋白 -  utrophin null(dko)小鼠用甘氨酸或L-丙氨酸(氨基酸对照)治疗长达15周和自愿跑步距离(生活质量标记和dko小鼠寿命的强相关性)和肌肉形态学评估。甘氨酸在2周后使mdx小鼠的自主跑步距离增加90%(P <0.05),并且在8周治疗期间与泼尼松龙共同治疗的dko小鼠中自愿跑步距离增加60%(P <0.01)。甘氨酸处理在mdx小鼠中10周后减弱了隔膜中的纤维化沉积(P <0.05),并且在dko小鼠中14周后减少了22%(P <0.02)。

Prednisolone Acetate

呼吸 肾上腺皮质激素类药物 药物
概述  :  

基本信息 醋酸泼尼松龙片药品主要成分为醋酸泼尼松龙,化学式:11β,17α,21-三羟基孕甾-1,4-二烯-3,20-二酮-21-醋酸酯。分子式:C23H30O6。分子量:402.49。 作用机制醋酸泼尼松龙为肾上腺皮质激素类药物。具有抗炎、抗过敏和抑制免疫等多种药理作用。(1)抗炎作用:糖皮质激素减轻和防止组织对炎症的反应,从而减轻炎症的表现。(2)免疫抑制作用:防止或抑制细胞中介的免疫反应、延迟性的过敏反应,并减轻原发免疫反应的扩展。(3)抗毒、抗休克作用:糖皮质激素能对抗细菌内毒

prednisolone   /prɛd'nɪsə,lon/

       n. 脱氢皮质醇,泼尼松龙(一种糖皮质激素)

       Of 687 children included in the intent-to-treat analysis, 343 were in the prednisolone group and 344 in the placebo group. 参与治疗意向分析的687名儿童中,泼尼松龙组343名,安慰剂组344名。

 

Acetate   /'æsɪtet/ 

       n. [有化] 醋酸盐

同根词   acetose adj. 醋一样酸的;制造醋的;醋酸的

               acetin n. [食品] 醋精;[生化] 乙酸甘油酯;甘油醋酸酯

               acetum n.醋;醋酸溶液

       Measure the peak area for acetate. 测出醋酸盐的峰面积。

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