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airway microbiome

呼吸

关键词呼吸 临床研究术语 疾病、免疫相互作用

词汇介绍

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解析

Airway   英 [ˈɛːweɪ]   美 [ˈɛrweɪ]

       n.气管;航路;空中航线;导气管;通风道;航空公司

       Airway abnormalities seen in the study were due to inflammatory changes, researchers said. 研究人员说,这项研究中所见的呼吸道异常是由于炎症变化引起的。


microbiome

       微生物组,微生物群系

       Number of observed orthologous groups in each caecal microbiome are similar. 每个盲肠菌群中观察到的同源群数是相似的。

概述

研究证实,健康成人下呼吸道存在微生物,且微生物种类多种多样,如细菌“门”类有:拟杆菌门、厚壁菌门、防线菌门及梭杆菌门。细菌属类有:普氏菌属、韦永氏球菌氏、链球菌属及假单胞菌属。不同疾病中,气道菌群结构存在差异。健康人上下呼吸道微生物组学存在差异健康人下呼吸道细菌种类和上呼吸道最为相似,但是相对丰度略有差别。以“门”为分类起点,健康人的下呼吸道细菌门类主要包括:拟杆菌门、厚壁菌门及变形菌门。最主要的细菌属类包括普氏菌属、韦永氏球菌属、链球菌属及假单胞菌属。下呼吸道不同部位微生态是否存在差异一项

Different Functional Genes of Upper Airway Microbiome Associated with Natural Course of Childhood Asthma复制标题

与儿童哮喘自然病程相关的上呼吸道菌群不同功能基因

发表时间:2018-03-21

影响因子:6.8

作者: Bong-Soo Kim

期刊:Allergy

Asthma is a complex heterogeneous disease accompanied by chronic inflammation of the airway. Since healthcare costs for asthmatic patients are rising, mainly due to the severity and/or persistence of the disease,identifying the phenotype and the underlying pathophysiology is essential. The natural history of childhood asthma reveals individual diversity.The previous studies identified several factors that increase the risk of persistent wheezing in children, some factors still need to be clarified.Atopy might affect the persistence of troublesome asthma,and progression of early airway inflammation to the substantial airway remodeling observed in those with persistent asthma may be explained by differences in inflammatory pathways.The airway microbiome might play a role in airway remodeling in children through various immune and inflammatory pathways, there by affecting the natural course of asthma.Therefore, identifying the role of the airway microbiome and its associated pathways might facilitate the development of novel therapeutics or prognositics that could help alter disease course.

译文

哮喘是一种复杂的异质性疾病,伴有气道的慢性炎症。由于哮喘患者的医疗保健成本上升,主要是由于疾病的严重性和/或持续性,因此识别表型和潜在的病理生理学是必要的。儿童哮喘的自然史揭示了个体的多样性。以往的研究发现了几种可能增加儿童持续性喘息风险的因素,有些因素仍有待澄清。可能会影响哮喘的持续存在,以及早期气道炎症的进展。在持续性哮喘患者中观察到的实质性气道重塑可以通过炎症通路的差异来解释。气道微生物组可能通过各种免疫和炎症途径在儿童气道重塑中发挥作用,从而影响哮喘的自然病程。因此,鉴定气道微生物组及其相关途径的作用可能有助于开发可以帮助改变疾病进程的新疗法或预后。