Different Functional Genes of Upper Airway Microbiome Associated with Natural Course of Childhood Asthma复制标题

与儿童哮喘自然病程相关的上呼吸道菌群不同功能基因

Asthma is a complex heterogeneous disease accompanied by chronic inflammation of the airway. Since healthcare costs for asthmatic patients are rising, mainly due to the severity and/or persistence of the disease,identifying the phenotype and the underlying pathophysiology is essential. The natural history of childhood asthma reveals individual diversity.The previous studies identified several factors that increase the risk of persistent wheezing in children, some factors still need to be clarified.Atopy might affect the persistence of troublesome asthma,and progression of early airway inflammation to the substantial airway remodeling observed in those with persistent asthma may be explained by differences in inflammatory pathways.The airway microbiome might play a role in airway remodeling in children through various immune and inflammatory pathways, there by affecting the natural course of asthma.Therefore, identifying the role of the airway microbiome and its associated pathways might facilitate the development of novel therapeutics or prognositics that could help alter disease course.

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