Endoplasmic Reticulum 美 [ˌɛndoʊˌplæzmɪk rəˈtɪkjələm] 英 [ˌɛndəʊˈplazmɪk]
释 义 n.内质网
例 句 Part of the endoplasmic reticulum has no attached ribosomes. 内质网有一部分没有附着核糖体。
Stress 英 [stres] 美 [ strɛs]
释 义 n.压力；强调；重音
例 句 All preoperative stress fractures healed. 所有术前应力性骨折都得到愈合。
作者： Prabuddha S Pathinayake
Asthma is a heterogeneous, chronic inflammatory disease of the airways. It is a complex disease with different clinical phenotypes and results in a substantial socioeconomic burden globally. Poor understanding of pathogenic mechanisms of the disease hinders the investigation into novel therapeutics. Emerging evidence of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) has demonstrated previously unknown functions of this response in asthma development. A worsening of asthmatic condition can be brought on by stimuli such as oxidativestress,pathogenic infections, and allergen exposure. All of which can induce ER stress and activate UPR leading to activation f different inflammatory responses and dysregulate the innate immune functions in the airways. The UPR as a central regulator of asthma pathogenesis may explain several unknown mechanism of the disease onset, which leads us in new directions for future asthma treatments. In this review, we summarize and discuss the causes and impact of ER–UPR in driving the pathogenesis of asthma and highlight its importance in clinical implications.