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Prednisolone Acetate

呼吸

关键词呼吸 药物 临床用药

词汇介绍

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解析

prednisolone   /prɛd'nɪsə,lon/

释    义   n. 脱氢皮质醇,泼尼松龙(一种糖皮质激素)

例    句   The combination of prednisolone and azathioprine has only a minor effect, whereas the addition of ciclosporin attenuates protective antibody responses to influenza vaccination. 泼尼松龙和硫唑嘌呤联合应用的影响较小,而加用环孢素则减弱了针对流行性感冒接种的保护性抗体应答。

 

acetate   英 /'æsɪteɪt/   美 /'æsɪtet/

释    义   n. [有化] 醋酸盐;醋酸纤维素及其制成的产品

同根词   adj. acetose 醋一样酸的;制造醋的;醋酸的

               n. acetin [食品] 醋精;[生化] 乙酸甘油酯;甘油醋酸酯;acetum 醋;醋酸溶液

例    句   Rather than getting stored as fat, the main fate of alcohol is conversion into a substance called acetate. 酒精主要是转化为一种叫醋酸盐的物质,而不是作为脂肪储存。

概述

基本信息品名  醋酸泼尼松龙片化学式  C23H30O6分子量  402.5 g/mol结构式    作用机制 本品为肾上腺皮质激素类药物。具有抗炎、抗过敏和抑制免疫等多种药理作用。抗炎作用:糖皮质激素减轻和防止组织对炎症的反应,从而减轻炎症的表现。免疫抑制作用:防止或抑制细胞中介的免疫反应、延迟性的过敏反应,并减轻原发免疫反应的扩展。抗毒、抗休克作用:糖皮质激素能对抗细菌内毒素对机体的刺激反应,

A paper-based analytical device coupled with electrochemical detection for the determination of dexamethasone and prednisolone in adulterated traditional medicines复制标题

纸基分析装置与电化学检测联用测定掺假中药中地塞米松和泼尼松龙

发表时间:2019-10-31

影响因子:5.3

作者: Primpray Vitsarut

期刊:Anal. Chim. Acta

The adulteration of herbal medicines by dexamethasone or prednisolone is regarded as a serious problem in many communities. Herein, a novel platform for the separation and quantification of both target steroids in herbal medicines based on electrochemical paper-based analytical devices (ePADs) has been created. The ePAD was composed of Whatman SG81 chromatography paper, 3D-printed devices and a commercial screen-printed electrode. Whatman SG81 silica-coated paper was used for the separation of dexamethasone and prednisolone based on the difference in their partition coefficients during the flow of the mobile phase. The optimal mobile phase was composed of 60% ethyl acetate in cyclohexane and required 7min for separation. The separated steroids on the paper were then quantified by electrochemical detection using differential pulse voltammetry, in which the 3D-printed devices facilitated the measurement. Analytical detection ranges of 10-500 mu g mL(-1) were obtained for both dexamethasone and prednisolone (r(2) =0.988 and 0.994, respectively). The limits of detection for dexamethasone and prednisolone were 3.59 and 11.98 mu g mL(-1), respectively, whereas the limits of quantification were 6.00 and 20.02 mu g mL(-1), respectively. The amounts of both target steroids derived from real herbal medicine samples determined by the proposed method were comparable to those obtained with assays using standard high-performance liquid chromatography. In addition, a simple evaporation step can be used to increase the concentration of the samples before analysis. These ePADs are simple, low-cost, rapid, and very promising for on-site quantitative detection.

译文

地塞米松或泼尼松龙对草药的掺假在许多社区被认为是一个严重的问题。本文中,已经创建了一种用于基于电化学纸基分析装置(ePAD)分离和定量草药中两种靶类固醇的新平台。 ePAD由Whatman SG81色谱纸,3D打印设备和商业丝网印刷电极组成。 Whatman SG81二氧化硅涂层纸用于分离地塞米松和泼尼松龙,基于它们在流动相流动期间的分配系数的差异。最佳流动相由60%乙酸乙酯的环己烷溶液组成,需要7min进行分离。然后通过使用差分脉冲伏安法的电化学检测来量化纸上分离的类固醇,其中3D打印装置便于测量。地塞米松和泼尼松龙的分析检测范围为10-500μg/ mL(-1)(分别为r(2)= 0.988和0.994)。地塞米松和泼尼松龙的检出限分别为3.59和11.98μg/ mL(-1),而定量限分别为6.00和20.02μg/ mL(-1)。通过所提出的方法测定的来自真实草药样品的两种靶类固醇的量与使用标准高效液相色谱法的测定获得的量相当。此外,可以使用简单的蒸发步骤在分析之前增加样品的浓度。这些ePAD简单,低成本,快速且非常有希望用于现场定量检测。