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首页 > 医学词汇大全 > Fexofenadine Hydrochloride
Fexofenadine Hydrochloride

呼吸

关键词呼吸 药物 临床用药

词汇介绍

拓展阅读

解析

fexofenadine

释    义   非索非那定

例    句   Fexofenadine was the second era antihistamine drug used to treat anaphylaxis, and was not sedative and heart toxicity. 非索非那定是第二代抗组胺药物,用于治疗过敏性疾病,无嗜睡,无心脏毒性。

 

hydrochloride   英 /,haɪdrə(ʊ)'klɔːraɪd/   美 /,haɪdrə'kloraɪd/

释    义   n. 盐酸盐;盐酸化物;氢氯化物

例    句   The synthetic methods of 5 bromo-2-aminothiazole, its hydrobromide and hydrochloride have been studied in this paper. 本文对5溴-2-氨基噻唑及其氢溴酸盐和盐酸盐的合成方法进行了研究。

概述

基本信息化学式  C32H40ClNO4分子量  538.1 g/mol结构式    作用机制  盐酸非索非那定是具有选择性外周 H1 受体拮抗作用的抗组胺药物。盐酸非索非那定在大鼠中抑制组胺从腹膜肥大细胞释放。在动物实验中,没有观察到抗胆碱、α1-肾上腺素或β-肾上腺素受体阻断作用,也未观察到镇静或其他中枢神经系统作用。本品不能通过血脑屏障。适应症 1、季节性过敏性鼻炎。适用于缓解成人和 6 岁及 6 岁以上年龄儿

Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy复制标题

非索非那定抑制钯过敏小鼠模型的迟发型超敏反应

发表时间:2017-07-25

影响因子:4.2

作者: Matsubara Ryota

期刊:Int J Mol Sci

Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. However, the precise mechanism of immune suppression in palladium allergy remains unknown. We investigated inhibition of the immune response in palladium allergic mice by administration of prednisolone as a glucocorticoid and fexofenadine hydrochloride as an antihistamine. Compared with glucocorticoids, fexofenadine hydrochloride significantly suppressed the number of T cells by interfering with the development of antigen-presenting cells from the sensitization phase. Our results suggest that antihistamine has a beneficial effect on the treatment of palladium allergy compared to glucocorticoids.

译文

钯经常用于牙科材料,有时会引起金属过敏。有人提出钯特异性T细胞的免疫应答可能是钯过敏模型小鼠研究中迟发型超敏反应的发病机制。在临床环境中,糖皮质激素和抗组胺药通常用于治疗接触性皮炎。然而,钯过敏中免疫抑制的确切机制仍然未知。我们研究了通过给予泼尼松龙作为糖皮质激素和盐酸非索非那定作为抗组胺药来抑制钯过敏小鼠的免疫应答。与糖皮质激素相比,盐酸非索非那定通过干扰来自致敏期的抗原呈递细胞的发育而显着抑制T细胞的数量。我们的结果表明,与糖皮质激素相比,抗组胺药对钯过敏的治疗具有有益作用。