释 义 非索非那定
例 句 Fexofenadine was the second era antihistamine drug used to treat anaphylaxis, and was not sedative and heart toxicity. 非索非那定是第二代抗组胺药物，用于治疗过敏性疾病，无嗜睡，无心脏毒性。
hydrochloride 英 /,haɪdrə(ʊ)'klɔːraɪd/ 美 /,haɪdrə'kloraɪd/
释 义 n. 盐酸盐；盐酸化物；氢氯化物
例 句 The synthetic methods of 5 bromo-2-aminothiazole, its hydrobromide and hydrochloride have been studied in this paper. 本文对5溴-2-氨基噻唑及其氢溴酸盐和盐酸盐的合成方法进行了研究。
作者： Matsubara Ryota
期刊：Int J Mol Sci
Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. However, the precise mechanism of immune suppression in palladium allergy remains unknown. We investigated inhibition of the immune response in palladium allergic mice by administration of prednisolone as a glucocorticoid and fexofenadine hydrochloride as an antihistamine. Compared with glucocorticoids, fexofenadine hydrochloride significantly suppressed the number of T cells by interfering with the development of antigen-presenting cells from the sensitization phase. Our results suggest that antihistamine has a beneficial effect on the treatment of palladium allergy compared to glucocorticoids.