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词汇介绍
拓展阅读
解析
fexofenadine
释 义 非索非那定
例 句 Fexofenadine was the second era antihistamine drug used to treat anaphylaxis, and was not sedative and heart toxicity. 非索非那定是第二代抗组胺药物，用于治疗过敏性疾病，无嗜睡，无心脏毒性。
hydrochloride 英 /,haɪdrə(ʊ)'klɔːraɪd/ 美 /,haɪdrə'kloraɪd/
释 义 n. 盐酸盐；盐酸化物；氢氯化物
例 句 The synthetic methods of 5 bromo-2-aminothiazole, its hydrobromide and hydrochloride have been studied in this paper. 本文对5溴-2-氨基噻唑及其氢溴酸盐和盐酸盐的合成方法进行了研究。
概述
基本信息
化学式 C32H40ClNO4
分子量 538.1 g/mol
结构式
作用机制
盐酸非索非那定是具有选择性外周 H1 受体拮抗作用的抗组胺药物。盐酸非索非那定在大鼠中抑制组胺从腹膜肥大细胞释放。在动物实验中，没有观察到抗胆碱、α1-肾上腺素或β-肾上腺素受体阻断作用，也未观察到镇静或其他中枢神经系统作用。本品不能通过血脑屏障。
适应症
1、季节性过敏性鼻炎。适用于缓解成人和 6 岁及 6 岁以上年龄儿童的季节性过敏性鼻炎相关的症状，如打喷嚏，流鼻涕，鼻、腭、喉部发痒、眼睛发痒、潮湿、发红。
2、慢性特发性荨麻疹。适用于治疗成人和 6 岁及 6 岁以上年龄儿童的慢性特发性荨麻疹的皮肤症状，能够显著减轻瘙痒和风团的数量。
禁忌症
对本品成分过敏者禁用。
不良反应
国外研究中出现的不良反应有头痛、恶心、痛经、倦睡、消化不良、上呼吸道感染、背痛、鼻窦炎等，同品种在中国人进行的临床试验中尚观察到 1 例患者治疗后出现尿蛋白、尿白细胞、尿红细胞，但与用药关系尚无法确定。
注意事项
不应与铝、镁制酸剂短时间内同时服用。
Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy
复制标题
非索非那定抑制钯过敏小鼠模型的迟发型超敏反应
发表时间：2017-07-25
影响指数：4.2
作者： Matsubara Ryota
期刊：Int J Mol Sci
Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. However, the precise mechanism of immune suppression in palladium allergy remains unknown. We investigated inhibition of the immune response in palladium allergic mice by administration of prednisolone as a glucocorticoid and fexofenadine hydrochloride as an antihistamine. Compared with glucocorticoids, fexofenadine hydrochloride significantly suppressed the number of T cells by interfering with the development of antigen-presenting cells from the sensitization phase. Our results suggest that antihistamine has a beneficial effect on the treatment of palladium allergy compared to glucocorticoids.
译文
