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首页 > 医学词汇大全 > Chlorpheniramine Maleate
Chlorpheniramine Maleate

呼吸

关键词呼吸 药物 皮肤过敏症

词汇介绍

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解析

chlorpheniramine    /,klɔ:fə'niərəmi:n/

释    义   n. 氯苯吡胺,扑尔敏

例    句   Simethicone and chlorpheniramine are effective for infant colic and can be combined with non-drug therapy. 西甲硅油和氯苯那敏对婴儿肠绞痛有明确的疗效,可与非药物治疗相结合。

 

maleate    /mə'li:it/

释    义   n. [有化] 马来酸盐(或酯);顺丁烯二酸盐(或酯);马来酸阴离子,顺丁烯二酸阴离子

同根词   adj. malay 马来人的;马来语的;马来西亚的

               n. malay 马来人;马来语

例    句   Sensitivity analysis showed that the cost-effectiveness ratio was identical if the price of Rosiglitazone-natrium was closed to that of Rosiglitazone maleate. 敏感性分析结果提示当罗格列酮钠价格接近马来酸罗格列酮的价格时两药品的成本效果才相当。

概述

基本信息化学式  C20H23ClN2O4分子量  390.9 g/mol结构式    作用机制作为组织胺 H1 受体拮抗剂,本品能对抗过敏反应(组胺)所致的毛细血管扩张,降低毛细血管的通透性,缓解支气管平滑肌收缩所致的喘息,本品抗组胺作用较持久,也具有明显的中枢抑制作用,能增加麻醉药、镇痛药、催眠药和局麻药的作用。本品主要在肝脏代谢。适应症 本品适用于皮肤过敏症:荨麻疹、湿疹、皮炎、药疹、皮肤瘙痒症、神经性皮炎、虫

Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures复制标题

复方扑热息痛、马来酸氯苯那敏和盐酸去氧肾上腺素的配伍研究

发表时间:2017-01-28

影响因子:3.6

作者: G.G.G. de Oliveira

期刊:Saudi Pharm J

Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1: 1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions.

译文

对乙酰氨基酚(PAR),盐酸苯肾上腺素(PHE)和马来酸氯苯那敏(CPM)在临床实践中通常用作解热和镇痛药物以改善感冒和流感病症中的疼痛和发烧。本工作描述了使用热分析来表征固体剂型开发过程中药物和赋形剂之间的物理化学相容性。热重分析(TGA)和差示扫描量热法(DSC)用于研究药物和物理混合物(药物/赋形剂)在固体二元混合物(1:1)中的热稳定性。 DSC热分析图显示制备的物理混合物的可重现的熔化事件。淀粉,甘露醇,乳糖和硬脂酸镁会影响热参数。从衍生热重(DTG)和TGA曲线记录的信息证明了药物在明确定义的热事件中的分解,转化了这些技术在药物/赋形剂相互作用表征中的适用性。