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首页 > 医学词汇大全 > Mometasone Furoate
Mometasone Furoate

呼吸

关键词呼吸 药物 过敏性鼻炎

词汇介绍

拓展阅读

解析

mometasone

释    义   莫米松

例    句   A randomized comparison of the effects of budesonide and mometasone furoate aqueous nasal sprays on nasal peak flow rate and symptoms in perennial allergic rhinitis. 随机试验比较布地奈德和糠酸莫米松鼻喷雾剂对常年性变应性鼻炎患者的鼻气道峰流速和鼻炎症状的作用。

 

furoate   /'fjurə,eit/

释    义   n. 糠酸盐

例    句   The properties, aroma characteristics and application of methyl-furoate were discussed. Methyl-furoate was synthesized by Cannizzaro reaction and esterification. 概述了糠酸甲酯的性质、香气特征和应用,通过康尼查罗反应和酯化反应合成了糠酸甲酯。

概述

基本信息品名  糠酸莫米松化学式  C27H30Cl2O6分子量  521.4 g/mol结构式  作用机制  糠酸莫米松是一种合成的外用糖皮质激素激动剂受体莫米松的糠酸盐形式,具有抗炎、抗瘙痒和收缩血管的特性。糠酸莫米松通过结合胞质糖皮质激素受体发挥作用,随后激活糖皮质激素受体介导的基因表达。这导致某些抗炎蛋白的合成,同时抑制某些炎症介质的合成。具体来说,糠酸莫米松似乎诱导磷脂酶A2蛋白抑制剂,从而控制磷脂酶A2

Serious asthma events with mometasone furoate plus formoterol compared with mometasone furoate复制标题

糠酸莫米松联合福莫特罗与糠酸莫米松的严重哮喘事件比较

发表时间:2019-04-11

影响因子:14.1

作者: Cindy L. J. Weinstein

期刊:J. Allergy Clin. Immunol.

The safety of long-acting beta-agonists added to inhaled corticosteroids for the treatment of persistent asthma has been controversial. We sought to determine whether administering formoterol in combination with mometasone furoate increases the risk of serious asthmaoutcomes (SAOs)compared with mometasone furoate alone. We conducted a 26-week, randomized, double-blind trial in adolescent and adult patients (> 12 years) with persistent asthma in 35 countries with the primary objective of evaluating whether mometasone furoate-formoterol increases the risk of SAOs (adjudicated hospitalization, intubation, or death) compared with mometasone furoate alone. The key efficacy end point was asthma exacerbation(composite of hospitalization of> 24 hours, emergency department visits of < 24 hours requiring systemic corticosteroids, or use of systemic corticosteroids for > 3 consecutive days). The addition of formoterol to mometasone furoate maintenance therapy did not increase the risk of serious asthma-related events and reduced the risk of asthma exacerbation.

译文

添加到吸入皮质类固醇中用于治疗持续性哮喘的长效β-激动剂的安全性一直存在争议。我们试图确定与单用糠酸莫米松相比,将福莫特罗与糠酸莫米松联合使用是否会增加严重哮喘预后(SAO)的风险。我们在35个国家的青少年和成年患者(> 12岁)进行了为期26周的随机双盲试验,其中主要目的是评估糠酸莫米松 - 福莫特罗是否会增加SAO的风险(判定住院,插管) ,或与单独的糠酸莫米松相比。关键疗效终点是哮喘急性加重(住院治疗> 24小时,急诊科就诊<24小时需要全身性皮质类固醇,或全身使用皮质类固醇连续3天)。福莫特罗加入糠酸莫米松维持治疗并未增加严重哮喘相关事件的风险,并降低了哮喘急性发作的风险。