呼吸
词汇介绍
拓展阅读
解析
mometasone
释 义 莫米松
例 句 A randomized comparison of the effects of budesonide and mometasone furoate aqueous nasal sprays on nasal peak flow rate and symptoms in perennial allergic rhinitis. 随机试验比较布地奈德和糠酸莫米松鼻喷雾剂对常年性变应性鼻炎患者的鼻气道峰流速和鼻炎症状的作用。
furoate /'fjurə,eit/
释 义 n. 糠酸盐
例 句 The properties, aroma characteristics and application of methyl-furoate were discussed. Methyl-furoate was synthesized by Cannizzaro reaction and esterification. 概述了糠酸甲酯的性质、香气特征和应用，通过康尼查罗反应和酯化反应合成了糠酸甲酯。
概述
基本信息
品名 糠酸莫米松
化学式 C27H30Cl2O6
分子量 521.4 g/mol
结构式
作用机制
糠酸莫米松是一种合成的外用糖皮质激素激动剂受体莫米松的糠酸盐形式，具有抗炎、抗瘙痒和收缩血管的特性。糠酸莫米松通过结合胞质糖皮质激素受体发挥作用，随后激活糖皮质激素受体介导的基因表达。这导致某些抗炎蛋白的合成，同时抑制某些炎症介质的合成。具体来说，糠酸莫米松似乎诱导磷脂酶A2蛋白抑制剂，从而控制磷脂酶A2从磷脂膜释放炎症前体花生四烯酸。
适应症
本品适用于季节性、常年性过敏性鼻炎，哮喘的预防与维持性治疗，炎性角化过度性皮肤病，季节性过敏性鼻炎导致的鼻塞，鼻息肉，预防季节性过敏性鼻炎等。
不良反应
胃肠道：腹痛，口腔念珠菌病，消化不良，恶心；
肌肉骨骼系统：背痛，肌肉骨骼疼痛，肌痛；
神经系统：头痛；
生殖系统：痛经；
呼吸系统：过敏性鼻炎，鼻出血，咽炎，上呼吸道感染。
禁忌
对糠酸莫米松及其任何组分过敏者；经口吸入药品禁忌用于已知对牛奶蛋白过敏的病人；吸入药品禁忌用于症状性哮喘的主要治疗或其他急性哮喘发作的强化干预治疗。
Serious asthma events with mometasone furoate plus formoterol compared with mometasone furoate
复制标题
糠酸莫米松联合福莫特罗与糠酸莫米松的严重哮喘事件比较
发表时间：2019-04-11
影响指数：14.1
作者： Cindy L. J. Weinstein
期刊：J. Allergy Clin. Immunol.
The safety of long-acting beta-agonists added to inhaled corticosteroids for the treatment of persistent asthma has been controversial. We sought to determine whether administering formoterol in combination with mometasone furoate increases the risk of serious asthmaoutcomes (SAOs)compared with mometasone furoate alone. We conducted a 26-week, randomized, double-blind trial in adolescent and adult patients (> 12 years) with persistent asthma in 35 countries with the primary objective of evaluating whether mometasone furoate-formoterol increases the risk of SAOs (adjudicated hospitalization, intubation, or death) compared with mometasone furoate alone. The key efficacy end point was asthma exacerbation(composite of hospitalization of> 24 hours, emergency department visits of < 24 hours requiring systemic corticosteroids, or use of systemic corticosteroids for > 3 consecutive days). The addition of formoterol to mometasone furoate maintenance therapy did not increase the risk of serious asthma-related events and reduced the risk of asthma exacerbation.
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