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首页 > 医学词汇大全 > triggering receptor expressed on myeloid cells 1
triggering receptor expressed on myeloid cells 1

呼吸

关键词呼吸 临床研究术语 炎症反应

词汇介绍

拓展阅读

解析

trigger   /'trɪgɚ/

释    义   n. [电子] 触发;起动

               v. 引起;扣…的扳机

例    句   We need as many people as possible to have access to this technology, because these advances are triggering a revolution in what human beings can do for one another. 我们要尽可能地让更多的人有机会使用这个技术,因为这些先进技术正在引发一场革命,其使人类可以互相帮助。

 

receptor   英 /rɪ'septə/   美 /rɪ'sɛptɚ/

释    义   n. [生化] 受体;接受器;感觉器官

同根词   adj. receptive 善于接受的;能容纳的

               n. receptivity 接受能力;[生理] 感受性;receptiveness 感受性;接受能力

例    句   These may bind to receptor molecules on the surfaces of cells. 这些可能会在细胞表面和受体分子结合在一起。

 

express   英 /ɪk'sprest/   美 /ɪkˈsprɛst; eksprestˈ; ɛkˈsprɛst/

释    义   v. 表达( express的过去式和过去分词 );(用符号等)表示;榨;(如在说话、写作或绘画中)表达(自己)的意见

例    句   She expressed her thanks to us. 她向我们表达了感谢之情。

 

myeloid   英 /'maɪəlɒɪd/

释    义   adj. 骨髓的;骨髓状的;由骨髓而来的;脊髓的

同根词   n. myelofibrosis [内科] 骨髓纤维化,骨髓纤维变性;myelography 脊髓照相术;[特医] 脊髓造影术;[特医] 脊髓X射线摄影术

例    句   The myeloid DC has different function during their different differentiation and development stage. 髓系树突状细胞分化发育的各阶段具有不同的功能特点。

 

cell   英 /sel/   美 /sɛl/

释    义   n. 细胞;电池;蜂房的巢室;单人小室

               vi. 住在牢房或小室中

同根词   n. cellularity 细胞性;多孔性;细胞结构

例    句   This is the web page of Cell Biochemistry and Biophysics . 这是细胞生物化学与生物物理学的网页。

概述

髓样细胞触发受体1 (TREM-1) 作为炎症反应的放大器在2001年首次由Bouchon 等提出,TREM-1通过一个相关的信号转导分子死亡相关蛋白12 ( death associated protein-12,DAP-12) 促进效应器细胞激活,从而触发促炎介质的分泌,与Toll 样受体( Toll-like receptors,TLR )协同放大微生物成分介导的炎症反应。结构  人类TREM-1基因定位于6p21染色体上,包含4个外显子,可转录两种RNA

TREM-1 Attenuates RIPK3-mediated Necroptosis in Hyperoxia-induced Lung Injury in Neonatal Mice.复制标题

TREM-1减轻新生小鼠高氧诱导RIPK3-mediated中的肺损伤坏死。

发表时间:2019-03-12

影响因子:4.3

作者: Syed MA

期刊:Am. J. Respir. Cell Mol. Biol.

Hyperoxia-induced injury to the developing lung, impaired alveolarization, and dysregulated vascularization are critical factors in the pathogenesis of bronchopulmonary dysplasia (BPD); however, mechanisms for hyperoxia-induced development of BPD are not fully known. In this study, we show that TREM-1 (triggering receptor expressed on myeloid cells 1) is upregulated in hyperoxia-exposed neonatal murine lungs as well as in tracheal aspirates and lungs of human neonates with respiratory distress syndrome and BPD as an adaptive response to survival in hyperoxia. Inhibition of TREM-1 function using an siRNA approach or deletion of the Trem1 gene in mice showed enhanced lung inflammation, alveolar damage, and mortality of hyperoxia-exposed neonatal mice. The treatment of hyperoxia-exposed neonatal mice with agonistic TREM-1 antibody decreased lung inflammation, improved alveolarization, and was associated with diminished necroptosis-regulating protein RIPK3 (receptor-interacting protein kinase 3). Mechanistically, we show that TREM-1 activation alleviates lung inflammation and improves alveolarization through downregulating RIPK3-mediated necroptosis and NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in hyperoxia-exposed neonatal mice. These data show that activating TREM-1, enhancing angiopoietin 1 signaling, or blocking the RIPK3-mediated necroptosis pathway may be used in new therapeutic interventions to control adverse effects of hyperoxia in the development of BPD.

译文

高氧诱导的肺部损伤,肺泡化受损和血管形成失调是支气管肺发育不良(BPD)发病的关键因素;然而,高氧诱导的BPD发展机制尚不完全清楚。在这项研究中,我们显示TREM-1(在骨髓细胞1上表达的触发受体)在高氧暴露的新生小鼠肺以及呼吸窘迫综合征和BPD作为适应性反应的人类新生儿的气管吸出物和肺中上调。高氧存活。使用siRNA方法抑制TREM-1功能或在小鼠中删除Trem1基因显示增强的肺部炎症,肺泡损伤和暴露于高氧的新生小鼠的死亡率。用激动性TREM-1抗体治疗暴露于高氧的新生小鼠减少了肺部炎症,改善了肺泡化,并且与减少的坏死性凋亡调节蛋白RIPK3(受体相互作用蛋白激酶3)相关。在机理上,我们显示TREM-1活化通过下调RIPK3介导的坏死性凋亡和NLRP3(含有pyrin结构域的核苷酸结合寡聚化结构域样受体3)炎症体激活在高氧暴露的新生小鼠中减轻肺部炎症并改善肺泡化。这些数据显示激活TREM-1,增强血管生成素1信号传导或阻断RIPK3介导的坏死性凋亡途径可用于新的治疗干预以控制高氧对BPD发展的不利影响。