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aerosol

呼吸

关键词呼吸 药物 药物剂型

词汇介绍

拓展阅读

解析

aerosol   英 /'eərəsɒl/   美 /'ɛrəsɔl/

       n. [物化] 气溶胶;气雾剂;喷雾器;浮质

               adj. 喷雾的;喷雾器的

同根词   vt. aerosolize 使成烟雾状散开

       If you are using Inhalation Aerosol, then the usual starting dose is 2 to 3 inhalations . 如果您是使用吸入气雾剂,然后惯常的起始剂量是2至3吸入。

概述

气雾剂系统是由阀门、容器、内容物( 药物、附加剂、抛射剂等) 组成的完整的压力包装,当阀门打开时,内容物以预定的压力、按控制的方式释放。气雾剂可将药物直接给入作用部位,起效快,可降低药物毒、副作用,近年发展较快,具体体现在包装容器、生产设备、工艺与技术等不断改进,应用范围、产品种类不断增加。尤其作为肽类及蛋白类药物非注射给药系统的一种,气雾剂越来越受到研究者的重视,目前广泛应用于医学领域。特点  该制剂可以使药物直接到达有效部位,在治疗部位快速达到有效作用浓度并维持一定的作用时间(

Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles.复制标题

用一种了解纳米颗粒气溶胶性能的新方法开发和评价用于肺输送的姜黄素纳米乳和微悬浮液制剂。

发表时间:2019-02-25

影响因子:4.2

作者: Al Ayoub Y

期刊:Int J Pharm

Extensive research has demonstrated the potential effectiveness of curcumin against various diseases, including asthma and cancers. However, few studies have used liquid-based vehicles in the preparation of curcumin formulations. Therefore, the current study proposed the use of nanoemulsion and microsuspension formulations to prepare nebulised curcuminoid for lung delivery. Furthermore, this work expressed a new approach to understanding the aerosol performance of nanoparticles compared to microsuspension formulations. The genotoxicity of the formulations was also assessed. Curcuminoid nanoemulsion formulations were prepared in three concentrations (100, 250 and 500 µg/ml) using limonene and oleic acid as oil phases, while microsuspension solutions were prepared by suspending curcuminoid particles in isotonic solution (saline solution) of 0.02% Tween 80. The average fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) of the nebulised microsuspension formulations ranged from 26% and 7.1 µm to 40% and 5.7 µm, for 1000 µg/ml and 100 µg/ml respectively. In a comparison of the low and high drug concentrations of the nebulised nanoemulsion, the average FPF and MMAD of the nebulised nanoemulsion formulations prepared with limonene oil ranged from 50% and 4.6 µm to 45% and 5.6 µm, respectively; whereas the FPF and MMAD of the nebulised nanoemulsion prepared with oleic acid oil ranged from 46% and 4.9 µm to 44% and 5.6 µm, respectively. The aerosol performance of the microsuspension formulations were concentration dependent, while the nanoemulsion formulations did not appear to be dependent on the curcuminoids concentration. The performance and genotoxicity results of the formulations suggest the suitability of these preparations for further inhalation studies in animals.

译文

广泛的研究证明了姜黄素对各种疾病(包括哮喘和癌症)的潜在有效性。然而,很少有研究使用液体载体制备姜黄素制剂。因此,目前的研究提出使用纳米乳剂和微悬浮液制剂来制备用于肺部递送的雾化类姜黄素。此外,与微悬浮液配方相比,这项工作表达了一种理解纳米粒子气溶胶性能的新方法。还评估了制剂的遗传毒性。使用柠檬烯和油酸作为油相以三种浓度(100,250和500μg/ ml)制备姜黄素纳米乳剂制剂,而通过将姜黄素颗粒悬浮在0.02%吐温80的等渗溶液(盐水溶液)中来制备微悬浮液。雾化微悬浮液制剂的平均细颗粒分数(FPF)和质量中位数空气动力学直径(MMAD)分别为26%和7.1μm至40%和5.7μm,分别为1000μg/ ml和100μg/ ml。在雾化纳米乳剂的低和高药物浓度的比较中,用柠檬油制备的雾化纳米乳剂制剂的平均FPF和MMAD分别为50%和4.6μm至45%和5.6μm;而用油酸油制备的雾化纳米乳的FPF和MMAD分别为46%和4.9μm至44%和5.6μm。微悬浮液制剂的气溶胶性能是浓度依赖性的,而纳米乳液制剂似乎不依赖于类姜黄素浓度。制剂的性能和遗传毒性结果表明这些制剂适用于动物的进一步吸入研究。