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autophagy

呼吸

关键词呼吸 临床研究术语 程序性细胞死亡

词汇介绍

拓展阅读

解析

autophagy   英 /ɔː'tɒfədʒɪ/   美 /ɔ'tɑfədʒi/

释    义   n. 自我吞噬;自食症;自体吞噬;自噬

例    句   The ability to activate autophagy within these cells could prove invaluable in the treatment of neurodegenerative disorders. 这种激活细胞自噬的能力对于神经系统变性疾病中的治疗意义重大。

概述

当前认为程序性细胞死亡(Programmed cell death)包括凋亡、自噬和坏死(Necrosis)。自噬,是真核细胞所特有的高度保守的细胞自我吞噬的过程,在不同的状态下被激活,所产生的效应也不同,在极端状态下被激活是为了保证细胞自身的存活,在正常状态下被激活是为了稳定细胞内环境。分类  自噬包括三种类型:巨自噬(macro—autophagy)、分子伴侣介导的自噬(Chaperone-mediated autograph,CMA)、微自噬(microautophagy),

Autophagy and inflammation in chronic respiratory disease复制标题

自噬与慢性呼吸系统疾病的炎症

发表时间:2017-11-24

影响因子:11.1

作者: Racanelli AC

期刊:Autophagy

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Chronic inflammation in the lung may arise from a combination of genetic susceptibility and environmental influences, including exposure to microbes, particles from the atmosphere, irritants, pollutants, allergens, and toxic molecules. To this end, an immediate, strong, and highly regulated inflammatory defense mechanism is needed for the successful maintenance of homeostasis within the respiratory system. Macroautophagy/autophagy plays an essential role in the inflammatory response of the lung to infection and stress. At baseline, autophagy may be critical for inhibiting spontaneous pulmonary inflammation and fundamental for the response of pulmonary leukocytes to infection; however, when not regulated, persistent or inefficient autophagy may be detrimental to lung epithelial cells, promoting lung injury. This perspective will discuss the role of autophagy in driving and regulating inflammatory responses of the lung in chronic lung diseases with a focus on potential avenues for therapeutic targeting.

译文

呼吸道内持续的炎症是许多慢性肺病的发病机制的基础,包括慢性阻塞性肺病,哮喘和肺纤维化。肺部的慢性炎症可能源于遗传易感性和环境影响的组合,包括暴露于微生物,大气中的颗粒,刺激物,污染物,过敏原和有毒分子。为此,需要立即,强大且高度调节的炎症防御机制来成功维持呼吸系统内的体内平衡。巨自噬/自噬在肺对感染和应激的炎症反应中起重要作用。在基线时,自噬可能对抑制自发性肺部炎症至关重要,也是肺白细胞对感染反应的基础;然而,当不受调节时,持续或低效的自噬可能对肺上皮细胞有害,促进肺损伤。这一观点将讨论自噬在驱动和调节慢性肺病肺部炎症反应中的作用,重点是治疗靶向的潜在途径。