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首页 > 医学词汇大全 > airway remodeling
airway remodeling

呼吸

关键词呼吸 临床研究术语 气道病变

词汇介绍

拓展阅读

解析

airway   英 /'eəweɪ/   美 /'ɛrwe/

释    义   n. 导气管;空中航线;通风孔;气道

例    句   To allow research in this field, accurate and standardised methods should be utilised to measure airway alterations in disease and following therapy. 在这一领域进行研究,需要使用精确和标准化的检测方法用以测定在疾病中和治疗后气道的改变。

 

remodeling   /ri'mɔdliŋ/

释    义   n. 重塑;重构(remodel进行式);改建

例    句   Atrial remodeling is the pathological basis of the occurrence and persistence of atrial fibrillation. 心房重构是发生心房颤动和心房颤动持续存在的病理基础。

概述

气道重塑是由气道正常结构发生病理性改变所引起,包括气道自身结构的改变和气道壁细胞结构、组分和功能的改变,主要病理生理学表现为气道增厚、缩窄,上皮下胶原蛋白、蛋白聚糖和糖蛋白沉积,上皮细胞脱落、间质化转变,杯状细胞增生、化生,气道平滑肌增生、增厚和血管生成等。机制研究  多数研究人员认为气道受到慢性炎症的长期刺激,组织反复损伤与修复,从而造成支气管壁结构发生改变是气道重塑的根本原因,且机体免疫细胞可通过分泌和释放多种炎性介质和细胞因子来影响气道重塑的发生。其主要机制包括:(1)上皮细

Airway remodeling in asthma: what really matters复制标题

哮喘的气道重塑: 真正重要的是

发表时间:2017-03-27

影响因子:3.4

作者: Fehrenbach H

期刊:Cell Tissue Res.

Airway remodeling is generally quite broadly defined as any change in composition, distribution, thickness, mass or volume and/or number of structural components observed in the airway wall of patients relative to healthy individuals. However, two types of airway remodeling should be distinguished more clearly: (1) physiological airway remodeling, which encompasses structural changes that occur regularly during normal lung development and growth leading to a normal mature airway wall or as an acute and transient response to injury and/or inflammation, which ultimately results in restoration of a normal airway structures; and (2) pathological airway remodeling, which comprises those structural alterations that occur as a result of either disturbed lung development or as a response to chronic injury and/or inflammation leading to persistently altered airway wall structures and function. This review will address a few major aspects: (1) what are reliable quantitative approaches to assess airway remodeling? (2) Are there any indications supporting the notion that airway remodeling can occur as a primary event, i.e., before any inflammatory process was initiated? (3) What is known about airway remodeling being a secondary event to inflammation? And (4), what can we learn from the different animal models ranging from invertebrate to primate models in the study of airway remodeling? Future studies are required addressing particularly pheno-/endotype-specific aspects of airway remodeling using both endotype-specific animal models and "endotyped" human asthmatics. Hopefully, novel in vivo imaging techniques will be further advanced to allow monitoring development, growth and inflammation of the airways already at a very early stage in life.

译文

气道重塑通常被广泛地定义为在患者的气道壁中观察到的相对于健康个体的组成,分布,厚度,质量或体积和/或结构组分的数量的任何变化。然而,应更清楚地区分两种类型的气道重塑:(1)生理性气道重塑,其包括在正常肺发育和生长期间经常发生的结构变化,导致正常的成熟气道壁或作为对损伤的急性和短暂反应, /或炎症,最终导致正常气道结构的恢复; (2)病理性气道重塑,其包括由于肺部发育受损或作为对慢性损伤和/或炎症的反应而导致持续改变的气道壁结构和功能而发生的那些结构改变。本综述将涉及几个主要方面:(1)什么是评估气道重塑的可靠定量方法? (2)是否有任何迹象表明气道重塑可能作为主要事件发生,即在任何炎症过程开始之前? (3)关于气道重塑是炎症的继发事件的已知事项? (4)在气道重塑研究中,我们可以从不同的动物模型中学到什么,从无脊椎动物到灵长类模型?未来的研究需要使用内特型特异性动物模型和“内型”人类哮喘患者来解决气道重塑的特别是表型/内型特异性方面。希望新的体内成像技术将进一步发展,以便在生命的早期阶段监测气道的发育,生长和炎症。