摘要

In order to verify the repeatability as well as the quantitative character of the measurements, we applied the proposed method for the detection of non-endogenous derivatives of NA in  urine. For this we selected N,N-diethyl nicotinamide (nikethamide, dENA), a respiratory  stimulant that affects the central nervous and  cardiovascular systems and is banned by the World Anti-Doping Agency (WADA). 
 


	
 


	Abuse of dENA may also be detected by its  metabolite N-ethyl nicotinamide (mENA), as neither occur endogenously. 23 Urine samples were spiked with both the compounds and subjected to the method herein. The result after the three layers of filtering described above is illustrated in the 1D spectrum in Fig. 4, in which NA, dENA and mENA each have one baseline resolved peak. 
 


	
 


	The repeatability of the method was investigated by collecting urine samples from five individuals and spiking them to 2 μM of dENA and mENA. Good repeatability was found, as indicated by the RSD of 5.7% and 12.0% for dENA and mENA, respectively.

译文

为了验证测量的重复性和定量特征,我们将所提出的方法应用于尿液中钠的非内源性衍生物的检测。为此,我们选择了N,N-二乙基烟酰胺(nikethamide,dENA),一种影响中枢神经和心血管系统的呼吸兴奋剂,被世界反兴奋剂机构(WADA)禁止。

其代谢产物N-乙基烟酰胺(mENA)也可检测到dENA的滥用,因为两者都不是内源性的。23份尿样中加入了这两种化合物,并采用本文所述的方法。上述三层滤波后的结果在图4的1D光谱中示出,其中NA、dENA和mENA各有一个基线分辨峰。

方法的重复性是通过收集5个人的尿液样本,并将其加入到2μM的dENA和mENA中来研究的。重复性好,dENA和mENA的RSD分别为5.7%和12.0%。

Nikethamide

呼吸 中枢神经系统兴奋药 药物
概述  :  

药物特征 尼可刹米选择性兴奋延髓呼吸中枢,使呼吸加深加快,也可作用于颈动脉体和主动脉体化学感受器,反射性地兴奋呼吸中枢,并提高呼吸中枢对CO2的敏感性,使呼吸加深加快。对血管运动中枢有微弱兴奋作用,剂量过大可引起惊厥。 体内过程 尼可刹米吸收好,起效快,作用时间短暂,一次静脉注射只能维持作用5~10分钟,进入体内后迅速分布至全身,在体内代谢为烟酰胺,然后再被甲基化为N-甲基烟酰胺,经尿液排出。

Nikethamide   /nɪ'kɛθəmɪd/

释    义   n. 可拉明;[药] 尼可刹米

例    句   To evaluate the clinical effects of nikethamide therapy on pulmonary tuberculosis induced respiratory failure. 评价尼可刹米治疗肺结核性呼吸衰竭的临床疗效。

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