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Loratadine

呼吸

关键词呼吸 治疗药物 临床用药

词汇介绍

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解析

Loratadine

       n. 氯雷他定(药名)

       Food additives are the most common allergens in atopic dermatitis. Combined montelukast and loratadine therapy is effective for children atopic dermatitis. 食品添加剂是儿童特应性皮炎主要的过敏原,孟鲁司特联合氯雷他定治疗儿童特应性皮炎有效。

概述

基本信息品名  息斯敏化学式  C22H23ClN2O2分子量  382.888 g/mol结构式   作用机制  氯雷他定是一种三环类抗组胺药,具有抗过敏和镇静作用。氯雷他定可阻断H1组胺受体,并可预防由组胺对毛细血管、支气管平滑肌和胃肠平滑肌的活性引起的症状,包括血管扩张、毛细血管通透性增加、支气管收缩和胃痉挛性收缩。肠系膜平滑肌。氯雷他定不会穿过血脑屏障,也不会对中枢神经系统产生影响。氯雷他

Development of novel electrochemical sensor on the base of molecular imprinted polymer decorated on SiC nanoparticles modified glassy carbon electrode for selective determination of loratadine复制标题

基于SiC纳米粒子修饰的分子印迹聚合物修饰玻碳电极的电化学传感器的研制选择性测定氯雷他定

发表时间:2017-02-12

影响因子:5.0

作者: Roushani Mahmoud

期刊:Mater Sci Eng C Mater Biol Appl

Loratadine (LOT), is a potent tricyclic antihistaminic compound with selective peripheral histamine H1-receptor activity that exhibits long-lasting effects. It is widely used for the relief of allergic seasonal symptom, such as sneezing, watery eyes, skin rash, itching, hives and runny nose. In the literature, different analytical procedures were reported for determination of LOT; including spectrophotometry , electrochemistry , densitometry , fluorescence , capillary electrophoresis and chromatography . Among the various reported methods, the electrochemical methods are viable alternatives for determination of LOT in pharmaceutical formulations due to some advantages, such as simplicity of operation, selectivity, having inexpensive techniques with high speed, and rapidity of data acquisition which makes them very competitive methods and usually the best choice for determination of electro-active compounds, and being suitable for routine analysis.

译文

氯雷他定(LOT)是一种有效的三环抗组胺化合物,具有选择性外周组胺H1受体活性,具有长效作用。 它广泛用于缓解过敏性季节性症状,如打喷嚏,流眼泪,皮疹,瘙痒,荨麻疹和流鼻涕。 在文献中,报道了不同的分析程序用于测定LOT; 包括分光光度法,电化学,光密度测定法,荧光,毛细管电泳和色谱法。 在各种报道的方法中,电化学方法是用于测定药物制剂中LOT的可行替代方案,因为它具有一些优点,例如操作简单,选择性,具有高速的廉价技术和数据采集的快速性,这使得它们成为非常有竞争力的方法。 通常是测定电活性化合物的最佳选择,适合常规分析。