BAMSE IgE MeDALL Phl p 4 allergen molecules allergic rhinitis cohort grass pollen microarray
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摘要

BACKGROUND:Grass pollen allergy is one of the most common allergies worldwide.
OBJECTIVE:To evaluate the usefulness of grass pollen allergen molecules for prediction of grass pollen allergy during childhood up to adolescence.
METHOD:Questionnaire data and sera obtained at 4, 8 and 16 years from the population-based BAMSE birth cohort were used. Sera from 763 representative subjects with serum samples available at all three ages were analysed for IgE-reactivity to 8 Phleum pratense allergens (MeDALL-chip) and to timothy extract (ImmunoCAP). Allergic rhinitis to grass pollen (ARg) was defined as upper airway symptoms during grass pollen exposure.
RESULTS:The prevalence of sensitization to any Phl p molecule was higher compared to timothy extract at all three ages; 4 (9.7% vs. 6.8%), 8 (28.4% vs 15.3%) and 16 (37.1% vs. 27.1%) years. General estimating equations (GEE) analyses revealed that among children sensitized at 4 years, the overall odds ratio (OR) of later ARg (up to 16 years) was increased only for IgE-reactivity to Phl p 1 (OR=4.9) and nPhl p 4 (OR=6.9). The likelihood of later symptoms increased with the number of allergen molecules; at 4 years ≥2 molecules predicted ARg to 78% and ≥3 molecules 95%. A positive test for timothy extract predicted ARg to 70%.
CONCLUSIONS:nPhl p 4 is a hitherto unrecognized early indicator of grass pollen allergy, in addition to Phl p 1. To identify grass pollen sensitization and predict later ARg, allergen molecules are of added value to timothy extract and may help clinicians improve prediction of grass pollen allergy.

译文

背景: 草花粉过敏是世界范围内最常见的过敏之一。
目的: 评估草花粉过敏原分子对儿童至青少年草花粉过敏的预测作用。
方法: 使用问卷调查数据和从基于人群的 BAMSE 出生队列中获得的 4 年、 8 年和 16 年的血清。分析了来自 763 名具有代表性的受试者的血清,以及所有三个年龄可获得的血清样本,以确定其对 8 种 Phleum pratense 过敏原 (MeDALL-chip) 和梯牧草提取物 (ImmunoCAP) 的 IgE 反应性。草花粉过敏性鼻炎 (ARg) 被定义为草花粉暴露期间的上气道症状。
结果: 在所有三个年龄,对任何 Phl p 分子的致敏率都高于梯牧草提取物; 4 (9.7% vs. 6.8%),8 (28.4% vs 15.3%) 和 16 (37.1% vs 27.1%) 年。一般估计方程 (GEE) 分析显示,在 4 岁敏感的儿童中,后来的 ARg (长达 16 岁) 的总体比值比 (OR) 仅对 Phl p 1 (OR = 4.9) 和 nPhl p 4 (OR = 6.9) 的 IgE 反应性增加。后期症状的可能性随着过敏原分子数量的增加而增加; 4 岁时 ≥ 2 个分子预测 ARg 为 78%,≥ 3 个分子为 95%。梯牧草提取物的阳性试验预测 ARg 为 70%。
结论: 除 Phl p 1 外,nPhl p 4 是迄今未被认识的草花粉过敏的早期指标。为了识别草花粉致敏并预测以后的 ARg,过敏原分子对梯牧草提取物具有附加值,并可能帮助临床医生改善草花粉过敏的预测。

Allergy

呼吸 又称Ⅰ型超敏反应或过敏反应 临床研究术语
概述  :  

变态反应又叫Ⅰ型超敏反应或过敏反应,主要由特异性IgE抗体介导产生,可发生于局部,亦可发生于全身所导致的疾病又称特应症。引起Ⅰ型超敏反应的抗原特称变应原,主要是各种动物、植物、微生物和药物等无害抗原。I 型超敏反应发生迅速,再次接触变应原 2~30 分钟后即可发生。I 型超敏反应具有明显的个体差异和遗传背景,人群中有些个体对于无害抗原具有产生高水平IgE抗体的遗传倾向,这些个体称特应性个体。目前,普遍认为哮喘等过敏性疾病的发生除遗传因素外,与环境因素也密切相关。卫生学说是对I型超敏反应发生与

Allergy   英 /ˈælədʒi/   美 /ˈælərdʒi/ 

释    义   n. 过敏症;反感;厌恶

同根词   allergic adj.对…过敏的;对…极讨厌的

               allergenic adj. 引起过敏症的

               allergen n. [医] 过敏原

               allergist n. 过敏症专科医师

例    句   Mrs Nguyen believes her condition was caused by a life-long allergy to seafood. 阮女士相信,她的病情是由一种终身海鲜过敏症引起的。

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