释 义 n. 肉芽肿病
例 句 The differential diagnosis between Wegner's granulomatosis and lymphomatoid granulomatosis was discussed. 本文就韦格内肉芽肿病和淋巴瘤样肉芽肿的鉴别诊断进行了讨论。
释 义 n. 多血管炎，淋巴管炎
例 句 To study the clinical and pathological characteristics of microscopicpolyangiitis (MPA) with renal medium artery involvement. 探讨并发肾脏中等动脉受累的显微镜下型多血管炎（MPA）的临床与病理特点。
作者： Josef Wagner
Granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis) is a multi-system autoimmune disorder. Disease a etiopathogenesis is considered to be multi-factorial but includes a host genetic component, epigenetic modifications and the environment with an increased risk of developing GPA in farmers or those with a high occupational solvent exposure in the index year or during their working lifetime. Other studies have demonstrated an association with dust exposure, and a correlation between lifetime exposure to high doses of silica and anti-neutrophil cytoplasm antibody (ANCA) positivity. Patients with GPA have a higher rate of nasal colonisation by Staphylococcus aureus (60–70%) than the general population (20–30%), and the presence of persistent carriage has been associated with an increased risk of disease relapse during follow-up. A randomized controlled trial showed a reduction of relapses following daily administration of trimethoprim-sulfamethoxazole (TMP-SMX) administered over a 2-year period .These findings suggest that GPA patients have a perturbed nasal microbiota, which may be related or contribute to the high S. aureus colonisation rate.