The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.复制标题

肉芽肿性多血管炎患者鼻腔微生物组的组成和功能蛋白子系统: 一项初步研究。

Granulomatosis with polyangiitis (GPA, formerly Wegener’s granulomatosis) is a multi-system autoimmune disorder. Disease a etiopathogenesis is considered to be multi-factorial but includes a host genetic component, epigenetic modifications and the environment with an increased risk of developing GPA in farmers or those with a high occupational solvent exposure in the index year or during their working lifetime. Other studies have demonstrated an association with dust exposure, and a correlation between lifetime exposure to high doses of silica and anti-neutrophil cytoplasm antibody (ANCA) positivity. Patients with GPA have a higher rate of nasal colonisation by Staphylococcus aureus (60–70%) than the general population (20–30%), and the presence of persistent carriage has been associated with an increased risk of disease relapse during follow-up. A randomized controlled trial showed a reduction of relapses following daily administration of trimethoprim-sulfamethoxazole (TMP-SMX) administered over a 2-year period .These findings suggest that GPA patients have a perturbed nasal microbiota, which may be related or contribute to the high S. aureus colonisation rate.

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