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Improved haemodynamics but reduced arterial blood oxygenation, at rest and during exercise after long-term oral prazosin therapy in chronic cor pulmonale.
慢性肺源性心脏病长期口服哌唑嗪治疗后,在休息和运动期间改善了血液动力学,但降低了动脉血氧。

摘要

The effect of vasodilator therapy in chronic obstructive lung disease with pulmonary hypertension was evaluated in eight patients during oral prazosin therapy (2-10 mg day-1). After one week, prazosin reduced mean pulmonary artery pressure and pulmonary and systemic vascular resistance, and increased cardiac index both at rest and during exercise. Similarly improved haemodynamics were observed after two months of therapy. Arterial PO2 and oxygen saturation fell significantly after two months both at rest and during exercise, but were not changed after one week. Lung function tests were not altered by prazosin. Thus, although prazosin improves the haemodynamics in patients with chronic obstructive lung disease, caution is advised in long-term therapy since prazosin worsens the arterial blood oxygenation.

译文

在口服哌唑嗪治疗期间 (2-10 mg day-1),对 8 例慢性阻塞性肺病伴肺动脉高压患者的血管扩张治疗效果进行了评估。一周后,哌唑嗪降低了平均肺动脉压以及肺和全身血管阻力,并增加了休息和运动中的心脏指数。治疗两个月后观察到类似的血液动力学改善。休息和运动两个月后,动脉 PO2 和血氧饱和度显著下降,但一周后没有变化。哌唑嗪没有改变肺功能测试。因此,尽管哌唑嗪改善了慢性阻塞性肺病患者的血液动力学,但在长期治疗中建议谨慎,因为哌唑嗪会恶化动脉血氧。

Chronic cor pulmonale

呼吸 慢性肺心病 疾病
概述  :  

疾病概述 慢性肺源性心脏病(简称慢性肺心病)是由慢性支气管肺疾病、胸廓疾病或肺血管疾病引起肺循环阻力增加、肺动脉高压,进而引起右心室肥厚、扩大,甚至发生右心衰竭的心脏病。 致病因素或病理机制按原发病部位一般可分为4大类。(一)慢性支气管、肺疾病:这一类疾病最常见,我国慢性肺心病中继发于COPD者约占80%以上,其他如支气管哮喘、重症肺结核、支气管扩张、间质性肺疾病等晚期也可继发慢性肺心病。(二)严重的胸廓畸形:如严重的脊椎后、侧凸,脊椎结核,类风湿性脊柱炎,广泛胸膜增厚粘连和胸廓成形术

Chronic  英 /ˈkrɒnɪk/   美 /ˈkrɑːnɪk/ 

释    义   adj. 慢性的;长期的;习惯性的

同根词   chronically adv.长期地;慢性地;习惯性地

例    句   As an oncologist, my goal would be to one day see that we can transform cancer into a chronic disease. 她说:“作为一名肿瘤学家,我的目标是有一天能看到我们将癌症转变成一种慢性疾病。”

 

cor Pulmonale   /'kɔ:,pumə'næli/

释    义   n.肺心病

例    句   The LV function impaired in cor pulmonale in all-round wail.慢性肺心病患者存在左室功能全面损害。

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