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Ambroxol

呼吸

关键词呼吸 药物 祛痰药

词汇介绍

拓展阅读

解析

Ambroxol   /æmb'rɒksɒl/

释    义   氨溴索

例    句   18 guinea-pigs were randomized into normal control group, bronchial asthma group and ambroxol group. 18只豚鼠随机分为正常对照组、哮喘模型组、氨溴索组。

概述

药物概述商品名或别名:溴环己胺醇,沐舒坦,痰之保克,兰勃素缓释胶囊,奧勃素,全福乐舒痰液,Mucosolvan, Ambroxol, Transbroncho。分类:化学,人工合成的溴己新体内代谢物;治疗学,祛痰药;妊娠分类,C。 适应症和剂量适用于黏痰不易咳出的各种急、慢性支气管炎和肺部疾病,如:①慢性阻塞性肺疾病(COPD):COPD 的急性发作期,本品能提高一些抗生素在肺组织中的浓度,促进腺体分泌和纤毛运动,加速痰液从管壁脱落,从而提高抗生素疗效、缩短疗程。②伴有痰栓的

Ambroxol Effects in Glucocerebrosidase and a-Synuclein Transgenic Mice复制标题

氨溴索对葡萄糖苷酶和a-突触核蛋白转基因小鼠的影响

发表时间:2016-11-24

影响因子:9.5

作者: Migdalska-Richards A

期刊:Ann. Neurol.

The increasing evidence linking GCase with α-synuclein in both PD-GBA1 and idiopathic PD patients suggests that treatments capable of increasing GCase might be beneficial to PD patients both with and without GBA1 mutations. To this end, small molecular chaperones designed to cross the blood–brain barrier that are capable of increasing GCase activity are being investigated as a novel therapy for PD to decreaseα-synuclein levels. One such small molecular chaperone is ambroxol hydrochloride (ambroxol). Ambroxol was identified as a GCase chaperone after screening the library of US Food and Drug Administration–approved drugs with a thermal denaturation assay using wild-type GCase. To date, 2 ambroxol studies using wild-type mice or transgenic mice carrying a human transgene containing either N370S or L444P mutation failed to provide convincing evidence to determine whether ambroxol is capable of increasing GCase in the peripheral and neuronal tissues. Considering the potential importance of ambroxol as a novel treatment for PD and neuronopathic forms of GD, we have investigated the effect of ambroxol on wild-type mice, on mice expressing the L444P mutation in the murine Gba1 gene, and on mice overexpressing humanα-synuclein in the absence of mouseα-synuclein.

译文

在PD-GBA1和特发性PD患者中,越来越多的将GCase与α-突触核蛋白联系起来的证据表明,能够增加GCase的治疗可能对有或没有GBA1突变的PD患者都有益。为此,正在研究设计用于穿越血脑屏障的能够提高GCase活性的小分子伴侣作为PD降低α-突触核蛋白水平的新疗法。一种这样的小分子伴侣是盐酸氨溴索(ambroxol)。在使用野生型GCase进行热变性测定筛选美国食品和药物管理局批准的药物库后,将氨溴索确定为GCase分子伴侣。迄今为止,使用野生型小鼠或携带含有N370S或L444P突变的人类转基因的转基因小鼠进行的2次氨溴索研究未能提供令人信服的证据来确定氨溴索是否能够增加外周和神经元组织中的GCase。考虑到氨溴索作为治疗PD和GD的神经病形式的潜在潜在重要性,我们研究了氨溴索对野生型小鼠,鼠Gba1基因中表达L444P突变的小鼠以及过表达人α-突触核蛋白的小鼠的影响在没有小鼠α-突触核蛋白的情况下。