释 义 氨溴索
例 句 18 guinea-pigs were randomized into normal control group, bronchial asthma group and ambroxol group. 18只豚鼠随机分为正常对照组、哮喘模型组、氨溴索组。
作者： Migdalska-Richards A
The increasing evidence linking GCase with α-synuclein in both PD-GBA1 and idiopathic PD patients suggests that treatments capable of increasing GCase might be beneficial to PD patients both with and without GBA1 mutations. To this end, small molecular chaperones designed to cross the blood–brain barrier that are capable of increasing GCase activity are being investigated as a novel therapy for PD to decreaseα-synuclein levels. One such small molecular chaperone is ambroxol hydrochloride (ambroxol). Ambroxol was identified as a GCase chaperone after screening the library of US Food and Drug Administration–approved drugs with a thermal denaturation assay using wild-type GCase. To date, 2 ambroxol studies using wild-type mice or transgenic mice carrying a human transgene containing either N370S or L444P mutation failed to provide convincing evidence to determine whether ambroxol is capable of increasing GCase in the peripheral and neuronal tissues. Considering the potential importance of ambroxol as a novel treatment for PD and neuronopathic forms of GD, we have investigated the effect of ambroxol on wild-type mice, on mice expressing the L444P mutation in the murine Gba1 gene, and on mice overexpressing humanα-synuclein in the absence of mouseα-synuclein.