Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis.
氨溴索对单氯胺增强胃癌的衰减: 对幽门螺杆菌相关胃癌的可能预防。

摘要

The effects of combined administration of a reactive oxidant, monochloramine, and a mucoregulatory agent, ambroxol, on the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in inbred Wistar rats. After receiving oral MNNG and regular chow pellets for 25 weeks, rats received regular chow pellets or chow pellets containing 20% ammonium acetate, and normal tap water or water containing 30 mM sodium hypochlorite, with or without subcutaneous injection of ambroxol at high or low doses, until the end of the experiment at week 52. Treatment with both ammonium acetate and sodium hypochlorite, which produce monochloramine, significantly increased the incidence of gastric cancers at week 52, whereas concomitant administration of ambroxol with ammonium acetate and sodium hypochlorite significantly attenuated this enhanced gastric carcinogenesis. Results also revealed that ambroxol scavenged monochloramine. Because monochloramine is closely related to Helicobacter pylori-associated gastric carcinogenesis, these findings suggest that ambroxol may prevent H. pylori-associated gastric carcinogenesis.

译文

反应氧化剂、单氯胺和粘液调节剂氨溴索联合给药的效果, 在近交系 Wistar 大鼠中研究了 N-甲基-N '-硝基-N-亚硝基胍 (MNNG) 诱导胃癌的发展。口服 MNNG 和常规 chow 微丸 25 周后,大鼠接受含有 20% 乙酸铵的常规 chow 微丸或 chow 微丸,以及含有 30 毫米次氯酸钠的正常自来水或水, 有或没有皮下注射高或低剂量的氨溴索,直到 52 周实验结束。使用乙酸铵和产生一氯胺的次氯酸钠治疗,在 52 周显著增加胃癌的发病率, 而同时给予氨溴索与乙酸铵和次氯酸钠显著减弱了这种增强的胃癌发生。结果还显示氨溴索清除了一氯胺。因为一氯胺与幽门螺杆菌相关的胃癌发生密切相关,这些发现表明氨溴索可能预防幽门螺杆菌相关的胃癌发生。

Ambroxol

呼吸 祛痰药 药物
概述  :  

药物概述商品名或别名:溴环己胺醇,沐舒坦,痰之保克,兰勃素缓释胶囊,奧勃素,全福乐舒痰液,Mucosolvan, Ambroxol, Transbroncho。分类:化学,人工合成的溴己新体内代谢物;治疗学,祛痰药;妊娠分类,C。 适应症和剂量适用于黏痰不易咳出的各种急、慢性支气管炎和肺部疾病,如:①慢性阻塞性肺疾病(COPD):COPD 的急性发作期,本品能提高一些抗生素在肺组织中的浓度,促进腺体分泌和纤毛运动,加速痰液从管壁脱落,从而提高抗生素疗效、缩短疗程。②伴有痰栓的

Ambroxol   /æmb'rɒksɒl/

释    义   氨溴索

例    句   18 guinea-pigs were randomized into normal control group, bronchial asthma group and ambroxol group. 18只豚鼠随机分为正常对照组、哮喘模型组、氨溴索组。

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