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首页 > 医学词汇大全 > Amikacin
Amikacin

呼吸

关键词呼吸 药物 抗菌药物

词汇介绍

拓展阅读

解析

Amikacin   /'æmikəsin/

释    义   n. 阿米卡星

例    句   The pharmaceutics of Amikacin (AMK) in old patients with respiratory system infections was studied to provide a basis for clinical use. 研究阿米卡星(AMK)在老年呼吸系统感染患者体内的药动学,为临床合理用药提供依据。

概述

药物概述 阿米卡星对多种革兰阴性杆菌、革兰阳性球菌、铜绿假单胞菌及若干分枝杆菌属具有较强的抗菌活性。对多数细菌的作用与卡那霉素相似或略优,较庆大霉素为差,对厌氧菌无效。本品最突出的优点是对许多肠道革兰阴性杆菌和铜绿假单胞菌所产生的乙酰转移酶、磷酸转移酶和核苷转移酶等稳定,因此在临床分离的肠杆菌科细菌中,约70%以上对庆大霉素、妥布霉素和奈替米星等耐药的菌株对本品仍敏感。主要用于对庆大霉素等耐药的细菌感染,或在庆大霉素耐药性普遍存在的医院中作为首选药物。粒细胞减少或其他免疫缺陷患者合并严重革兰阴性

Rapid diagnosis of neonatal sepsis by PCR for detection of 16S rRNA gene, while blood culture and PCR results were similar in E.coli-predominant EOS cases复制标题

PCR检测16S rRNA基因快速诊断新生儿败血症,而大肠杆菌为主的EOS病例血培养和PCR结果相似

发表时间:2019-10-02

影响因子:3.0

作者: Mostafa I EL-Amir

期刊:Infect Drug Resist

Gram-negative bacteria isolated from blood culture showed antibiotic susceptibility to ofloxacin, ciprofloxacin, imipenem, and amikacin, and marked resistance to ampicillin, amoxicillin clavulanic acid, ceftriaxone, piperacillin, cefoxitin, and azithromycin. According to Gram-positive bacteria, they showed marked susceptibility to vancomycin followed by imipenem, then oxacillin, and amikacin. On the other hand, Gram-positive bacteria showed marked resistance against ampicillin, amoxicillin clavulanic acid, ofloxacin, ceftriaxone, and ciprofloxacin. E.coli which was the commonest organism isolated from EOS cases showed susceptibility to ofloxacin, ciprofloxacin, imipenem followed by amikacin, while S. aureus which was the commonest cause for LOS showed susceptibility to vancomycin followed by oxacillin and imipenem. Our results are similar to those of another study from Egypt, which found that imipenem and quinolones are the best antibiotics against Gram-negative bacteria, while 100% of the Gram-positive bacteria were susceptible to vancomycin.

译文

从血液培养物中分离出的革兰氏阴性细菌对氧氟沙星,环丙沙星,亚胺培南和阿米卡星表现出抗生素敏感性,对氨苄西林,阿莫西林克拉维酸,头孢曲松,哌拉西林,头孢西丁和阿奇霉素具有明显的耐药性。根据革兰氏阳性细菌,他们对万古霉素,亚胺培南,奥沙西林和丁胺卡那霉素表现出明显的敏感性。另一方面,革兰氏阳性细菌对氨苄西林,阿莫西林克拉维酸,氧氟沙星,头孢曲松和环丙沙星显示出显着的抗性。从EOS病例中分离出的最常见的微生物大肠杆菌对氧氟沙星,环丙沙星,亚胺培南接着是阿米卡星易感,而引起LOS的最常见的金黄色葡萄球菌则对万古霉素易感,其次是奥沙西林和亚胺培南。我们的结果与埃及的另一项研究相似,后者发现亚胺培南和喹诺酮类药物是革兰氏阴性菌的最佳抗生素,而革兰氏阳性菌中有100%对万古霉素敏感。