Long-term amikacin use. Effects on aminoglycoside susceptibility patterns of gram-negative bacilli.
长期使用阿米卡星。对革兰氏阴性杆菌氨基糖苷类药物敏感性模式的影响。

摘要

Amikacin sulfate was first used sparingly at our cancer center in 1976; since 1979, it has been the only aminoglycoside used for systemic cancer therapy for patients with granulocytopenia. As the development of resistance has been correlated with antibiotic use over time, we wished to determine if prolonged use of amikacin in our patients had led to increased amikacin resistance. A total of 1,129 strains were recovered from 315 patients during a 13-month period. Each species isolated per patient was considered once. Seven percent of the patients had amikacin-resistant strains (2.7% of isolates), and 10% of patients had gentamicin-resistant strains (4% of isolates). Amikacin resistance was significantly less than in an earlier study. Unrestricted use of amikacin has not led to a concomitant increase in amikacin resistance in gram-negative bacilli.

译文

硫酸阿米卡星于 1976年首次在我们的癌症中心谨慎使用; 自 1979年以来,它一直是唯一一种用于粒细胞减少患者全身癌症治疗的氨基糖苷类药物。随着时间的推移,耐药性的发展与抗生素的使用相关,我们希望确定在我们的患者中长期使用阿米卡星是否会导致阿米卡星耐药性的增加。在 13 个月的时间里,从 1,129 名患者中总共回收了 315 株菌株。每个患者分离的每个物种被考虑一次。7% 的患者有阿米卡星耐药菌株 (2.7% 的分离株),10% 的患者有庆大霉素耐药菌株 (4% 的分离株)。阿米卡星耐药性显著低于早期研究。无限制使用阿米卡星并没有导致革兰阴性杆菌对阿米卡星耐药性的同时增加。

Amikacin

呼吸 抗菌药物 药物
概述  :  

药物概述 阿米卡星对多种革兰阴性杆菌、革兰阳性球菌、铜绿假单胞菌及若干分枝杆菌属具有较强的抗菌活性。对多数细菌的作用与卡那霉素相似或略优,较庆大霉素为差,对厌氧菌无效。本品最突出的优点是对许多肠道革兰阴性杆菌和铜绿假单胞菌所产生的乙酰转移酶、磷酸转移酶和核苷转移酶等稳定,因此在临床分离的肠杆菌科细菌中,约70%以上对庆大霉素、妥布霉素和奈替米星等耐药的菌株对本品仍敏感。主要用于对庆大霉素等耐药的细菌感染,或在庆大霉素耐药性普遍存在的医院中作为首选药物。粒细胞减少或其他免疫缺陷患者合并严重革兰阴性

Amikacin   /'æmikəsin/

释    义   n. 阿米卡星

例    句   The pharmaceutics of Amikacin (AMK) in old patients with respiratory system infections was studied to provide a basis for clinical use. 研究阿米卡星(AMK)在老年呼吸系统感染患者体内的药动学,为临床合理用药提供依据。

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