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Cefixime

呼吸

关键词呼吸 药物 头孢菌素类药物

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解析

Cefixime   /sefə'leksɪn/

释    义   头孢克肟

例    句   The methods is reliable and accurate, it can be used for quality control the cefixime buccal tablets. 该方法可靠精准,可用于头孢克肟口含片的质量控制。

概述

药物概述头孢克肟为口服第三代头孢菌素,抗菌谱广,抗菌活性强,尤其对多数肠杆菌科细菌有较强活性,优于头孢克洛、头孢氨苄和头孢羟氨苄。金黄色葡萄球菌、表皮葡萄球菌、肠球菌属及青霉素耐药肺炎球菌一般对本品耐药,铜绿假单胞菌、不动杆菌属、无色杆菌属、黄杆菌属、梭杆菌属等也均耐药,类杆菌属和消化链球菌也多对本品耐药。适用于敏感菌引起的呼吸道、泌尿系统、胆道感染,猩红热及耳鼻喉感染。口服:成人 400mg,qd,或200mg,bid;治疗单纯性尿路感染用400mg单剂即可。儿童 8mg/(kg·d

Evaluation of gut bacterial community composition and antimicrobial resistome in pregnant and non-pregnant women from Saudi population 复制标题

沙特人群孕妇和非孕妇肠道细菌群落组成和抗菌药物抵抗的评价

发表时间:2019-07-21

影响因子:3.0

作者: Imran Khan

期刊:Infect Drug Resist

16S amplicon sequencing revealed that GM of pregnant and NP women were pre-dominantly comprised of phyla Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Bacterial diversity decreased in pregnant groups, whereas phylum Bacteroidetes declined significantly (p<0.05) in the first trimester. We noticed a relatively high abundance of butyrate-producing bacteria (eg, Faecalibacterium spp. and Eubacterium spp.) in the gut of pregnant women, whereas Prevotella copri was found at significantly (p<0.01) higher abundance in NP women. Moreover, about 14,694 isolates were identified and classified into 132 distinct species. The majority of the species belonged to phyla Firmicutes and Proteobacteria. About8,125 isolates exhibited resistance against antibiotics. Out of 73 resistant-species, Enterococcus was the most diverse genus and Escherichia coli was the highly prevalent bacterium. The majority of the isolates were resistant to antibiotics; trimethoprim/sulfamethoxazole, cycloserine, and cefixime. ARGs encoding resistance against aminoglycoside, macrolide,quinolone, β-lactam, and tetra-cycline antibiotics were predominantly found in genomic DNA of the stool samples.

译文

16S扩增子测序表明,孕妇和NP妇女的GM主要由Firmauteticutes,Bacteroidetes,Proteobacteria和Actinobacteria组成。孕妇组中细菌多样性下降,而孕前细菌类门细菌显着下降(p <0.05)。我们注意到孕妇的肠道中产生丁酸盐的细菌(例如,Faecalibacterium spp。和Eubacterium spp。)相对较高,而NP妇女中发现的普氏杆菌显着较高(p <0.01)。此外,已鉴定出约14694种分离物并将其分类为132个不同的物种。该物种的大多数属于坚韧菌门和变形杆菌。约有8,125株分离株表现出对抗生素的抗性。在73种抗性物种中,肠球菌是最多样化的属,而大肠杆菌是高度流行的细菌。大多数分离株对抗生素有抗药性。甲氧苄啶/磺胺甲恶唑,环丝氨酸和头孢克肟。主要在粪便样本的基因组DNA中发现了编码对氨基糖苷类,大环内酯类,喹诺酮类,β-内酰胺类和四环素类抗生素耐药的ARGs。