The intricate problems associated with the delivery and various unnecessary in vivo transitions of proteins and drugs needs to be tackled soon to be able to exploit the myriad of putative therapeutics created by the biotechnology boom. Nanomedicine is one of the most promising applications of nanotechnology in the field of medicine. It has been defined as the monitoring, repair, construction and control of human biological systems at the molecular level using engineered nanodevices and nanostructures. These nanostructured medicines will eventually turn the world of drug delivery upside down. PEGylation (i.e. the attachment of polyethylene glycol to proteins and drugs) is an upcoming methodology for drug development and it has the potential to revolutionise medicine by drastically improving the pharmacokinetic and pharmacodynamic properties of the administered drug. This article provides a total strategy for improving the therapeutic efficacy of various biotechnological products in drug delivery. This article also presents an extensive analysis of most of the PEGylated proteins, peptides and drugs, together with extensive clinical data. Nanomedicines and PEGylation, the latest offshoots of nanotechnology will definitely pave a way in the field of drug delivery where targeted delivery, formulation, in vivo stability and retention are the major challenges.

译文

:与蛋白质和药物的递送以及各种不必要的体内过渡相关的复杂问题需要尽快解决,以便能够利用由生物技术繁荣发展而来的无数推定疗法。纳米医学是纳米技术在医学领域最有前途的应用之一。它已被定义为使用工程化的纳米器件和纳米结构在分子水平上监测,修复,构建和控制人类生物系统。这些纳米结构药物最终将颠覆药物输送的世界。聚乙二醇化(即聚乙二醇与蛋白质和药物的连接)是药物开发的一种新方法,它具有通过彻底改善所给药药物的药代动力学和药效学性质来革新药物的潜力。本文提供了用于提高各种生物技术产品在药物输送中的治疗功效的总体策略。本文还对大多数PEG化的蛋白质,肽和药物进行了广泛的分析,并提供了广泛的临床数据。纳米药物和聚乙二醇化是纳米技术的最新分支,无疑将在药物递送领域铺平道路,在这些领域中,靶向递送,制剂,体内稳定性和保留性是主要挑战。

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