Selected plants documented as medicinal in an ethnobotanical study with the Nahua of the Sierra de Zongolica (Veracruz, Mexico) were evaluated for anti-inflammatory and antibacterial activity. One of the potential sides of action of anti-inflammatory drugs is the transcription factor NF-κB. This factor is essential for the immune, inflammatory, and acute phase responses. We therefore tested extracts from a total of 28 plants used by the Nahua Indians for their potential effect on the activation of the transcription factor NF-κB. The leaves of Tithonia diversifolia (Hemsl.) A. Gray (Asteraceae) was the only extract which showed inhibitory activity. Nonspecific DNA binding activities were not noticably influenced. Phytochemical studies to isolate the active principle and further biochemical studies in order to better understand the mode of action of this NF-κB inhibitor have been initiated. Five plants showed noteworthy antibacterial activity against some pathogenic (Staphylococcus aureus ATCC 25933 and Yersinia enterocolitica 03) and nonpathogenic (E. coli DSM 1077, Micrococcus luteus DSM 348) microorganism: Acacia cornigera, Cuscuta tinctoria, Ludwigia octovalvis, Lysiloma divaricata, and Tithonia diversifolia.

译文

:对与塞拉利昂德宗加利卡(Naerra of Zongolica)(墨西哥韦拉克鲁斯市)的纳瓦族人种植物学研究中证明为药用的植物进行了抗炎和抗菌活性评估。抗炎药的潜在作用之一是转录因子NF-κB。该因子对于免疫,炎症和急性期反应至关重要。因此,我们测试了纳瓦族印第安人使用的总共28种植物的提取物对转录因子NF-κB活化的潜在影响。 Tithonia diversifolia(Hemsl。)A. Gray(菊科)的叶子是唯一显示出抑制活性的提取物。非特异性DNA结合活性未受到明显影响。已经启动了植物化学研究以分离活性成分,并进行了进一步的生物化学研究以更好地了解这种NF-κB抑制剂的作用方式。五株植物对某些病原微生物(金黄色葡萄球菌ATCC 25933和小肠结肠炎耶尔森氏菌03)和非病原微生物(大肠杆菌DSM 1077,微球菌luteus DSM 348)表现出显着的抗菌活性:洋槐金合欢,弯角弯孢菌,路德维希乌卡托弗里斯和硅藻。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录