BACKGROUND:Paronychia has been reported in as many as 10% of patients treated with gefitinib. Although conservative management and treatment with topical or systemic antibiotics are beneficial, no effective method exists for intractable cases. Platelet-rich plasma (PRP)consists of a high concentration of platelets that promote wound healing through chemotaxis, cell proliferation,angiogenesis, and tissue remodeling. OBSERVATIONS:We herein report a refractory case of gefitinib-induced paronychia successfully treated with autologous PRP. A 68-year-old woman who had been diagnosed as having lung adenocarcinoma with multiple bone and brain metastases initiated gefitinib therapy at an oral dose of 250 mg/d. After 1 month, multiple paronychia with periungual granulation appeared on the nailfold of the first, second, and third toenails of both feet.Because the paronychia recurred repeatedly despite use of a topical antibiotic, topical corticosteroid, and short term systemic antibiotic, she started PRP treatment. After 3 months, the lesion showed marked improvement with minimal pain or discharge. CONCLUSION:This case highlights the therapeutic challenges of using PRP to promote tissue repair in intractable gefitinib-induced paronychia and merits further investigation.

译文

背景:据报道,吉非替尼治疗的患者中有多达10%患有甲旁沟炎。尽管保守治疗和局部或全身性抗生素治疗是有益的,但对于顽固性病例,尚无有效方法。富含血小板的血浆(PRP)由高浓度的血小板组成,这些血小板通过趋化性,细胞增殖,血管生成和组织重塑促进伤口愈合。
观察:我们在这里报道了吉非替尼诱导的自体PRP成功治疗的顽固性病例。一名被确诊患有多发性骨和脑转移的肺腺癌的68岁妇女开始以250 mg / d的口服剂量进行吉非替尼治疗。 1个月后,双脚第一,第二和第三趾甲的指甲褶上出现多发性甲状旁腺肉芽肿,尽管使用了局部抗生素,局部皮质类固醇和短期全身性抗生素,但甲状旁腺反复发作,因此开始进行PRP。治疗。 3个月后,病变表现出明显的改善,疼痛或分泌物最少。
结论:该病例突出了在难治性吉非替尼诱导的甲状旁腺中使用PRP促进组织修复的治疗挑战,值得进一步研究。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录