Plasmodium falciparum malaria continues to threaten human populations in the tropics and travellers in endemic areas. Drug resistance of the parasite is a major problem in treating this devastating disease. In a prospective trial we investigated the in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine in the Albert Schweitzer Hospital in Lambaréné, Gabon every second year from 1992 to 1998. We used the standard WHO in vitro sensitivity assay. Parasite sensitivity to quinine and mefloquine remained stable over the years. However, parasite resistance to chloroquine decreased highly significantly with the change in local malaria treatment policy. In 1992, 100% of parasite isolates showed resistance to chloroquine, whereas in 1998 only 45% were found resistant.

译文

恶性疟原虫疟疾继续威胁热带地区的人口和流行地区的旅行者。寄生虫的耐药性是治疗这种破坏性疾病的主要问题。在一项前瞻性试验中,我们从1992年至1998年每隔第二年在加蓬Lambaréné的Albert Schweitzer医院调查了恶性疟原虫对氯喹,奎宁和甲氟喹的体外敏感性。我们使用了标准的WHO体外敏感性测定。这些年来,寄生虫对奎宁和甲氟喹的敏感性保持稳定。但是,随着当地疟疾治疗政策的改变,对氯喹的寄生虫抵抗力大大降低。在1992年,100%的寄生虫分离株显示出对氯喹的抗药性,而在1998年,发现只有45%的抗药性。

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