BACKGROUND:Human African trypanosomiasis (sleeping sickness), an endemic disease, is currently reemerging in Africa with an estimated incidence of 45,000 new cases per year. It is caused by Trypanosoma brucei subspecies and transmitted by day-biting tsetse flies. PATIENTS AND METHODS:We report a case of West African trypanosomiasis due to Trypanosoma brucei gambiense involving a Frenchman living in Libreville, Gabon. The patient presented with fever and polyadenopathies as well as two skin ulcerations highly suggestive of trypanosomiasis. Microscopic examination of cutaneous and peripheral blood smears confirmed the diagnosis of haemolymphatic infection with T. b. gambiense with trypanosomal chancres. Examination of the cerebrospinal fluid was normal. The patient was successfully treated with pentamidine isethionate. CONCLUSIONS:Recognition of cutaneous manifestations may allow a rapid diagnosis of African trypanosomiasis that is essential for timely and efficient treatment and survival.

译文

背景:人类锥虫病(昏睡病)是一种地方性疾病,目前正在非洲重新流行,估计每年发生45,000例新病例。它是由布鲁氏锥虫亚种引起的,并且是由叮咬的采采蝇传播的。
病人和方法:我们报告了一例西非锥虫病,该病例是由法国人居住在加蓬利伯维尔的布鲁氏锥虫引起的。该患者出现发烧,多腺病以及两次皮肤溃疡,强烈提示锥虫病。皮肤和外周血涂片的显微镜检查证实了T. b的血淋巴感染的诊断。甘菊与锥虫性小结。脑脊液检查正常。该患者已成功使用喷他is乙羟乙磺酸盐治疗。
结论:认识到皮肤表现可能可以快速诊断非洲锥虫病,这对于及时有效的治疗和生存至关重要。

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