Most living systems, ranging from animal flocks, self-motile microorganisms to the cytoskeleton rely on self-organization processes to perform their own specific function. Despite its importance, the general understanding of how individual active constituents initiate the intriguing pattern formation phenomena on all these different length scales still remains elusive. Here, using a high density actomyosin motility assay system, we show that the observed collective motion arises from a seeding process driven by enhanced acute angle collisions. Once a critical size is reached, the clusters coarsen into high and low density phases each with fixed filament concentrations. The steady state is defined by a balance of collision induced randomization and alignment effects of the filaments by multi-filament collisions within ordered clusters.Self-organization is observed in cytoskeletal systems but emergence of order from disorder is poorly understood. Using a high density actomyosin system, the authors capture the transition from disorder to order, which is driven by enhanced alignment effects caused by increase in multi-filament collisions.

译文

:从动物群,自我活动性微生物到细胞骨架的大多数生命系统都依赖于自我组织过程来执行其自身的特定功能。尽管它很重要,但是对于各个活性成分如何在所有这些不同的长度尺度上引发有趣的图案形成现象的一般理解仍然是难以捉摸的。在这里,使用高密度放线菌素运动分析系统,我们显示观察到的集体运动是由增强的锐角碰撞驱动的播种过程产生的。一旦达到临界尺寸,簇就粗化为高密度相和低密度相,每个相都具有固定的灯丝浓度。稳态是由碰撞诱导的随机化和在有序簇内的多丝碰撞引起的长丝排列效应之间的平衡所定义的。在细胞骨架系统中观察到自组织,但对从无序出现的顺序了解甚少。使用高密度放线菌素系统,作者捕获了从无序到有序的过渡,这是由多丝碰撞增加引起的增强排列效果驱动的。

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