BACKGROUND:Clinical studies reported that treatments for Alzheimer's disease may have an impact on behavioral and psychiatric disorders. We tested the hypothesis that memantine treatment initiation modifies psychotropic medication in real-life practice patients. METHODS:A 2-year follow-up cohort study was performed. A sample of patients treated in the general population, extracted from the database of the French national healthcare system (CNAM-TS), was examined. The sample included 4,600 memantine-treated patients (mean age 79.8 years, 69% women) randomly selected from the database of the CNAM-TS covering 69% of the French population aged 65 years and over. The follow-up rate was 95.0%. This database includes exhaustive data on drug consumption. We used interrupted time series analysis of the proportion of psychotropics users (all psychotropic drugs and specific categories) before and after onset of memantine. RESULTS:There was a 39-50% regular increase in patients treated with psychotropic drugs before memantine initiation This increasing trend stopped after memantine initiation, the proportion of psychotropic users remaining stable around 53% up to the end. The trends before and after memantine onset were significantly different (p < 0.001). CONCLUSIONS:Our results suggest a temporal relationship between the onset of memantine and the stabilization of psychotropic drugs use in this large sample of elderly patients.

译文

背景:临床研究报道,阿尔茨海默氏病的治疗方法可能会对行为和精神疾病产生影响。我们测试了美金刚胺治疗开始会改变现实生活中的患者的精神药物的假设。
方法:进行了为期2年的随访队列研究。从法国国家医疗保健系统(CNAM-TS)的数据库中提取了在一般人群中接受治疗的患者样本。该样本包括从CNAM-TS数据库中随机选择的4,600名接受美金刚治疗的患者(平均年龄79.8岁,女性占69%),覆盖了69%的法国65岁及以上人口。随访率为95.0%。该数据库包括有关毒品消费的详尽数据。我们在美金刚发作前后对精神药物使用者(所有精神药物和特定类别)的比例进行了中断时间序列分析。
结果:美金刚开始治疗前接受精神药物治疗的患者有39-50%的常规增加。美金刚开始治疗后这种增长趋势停止了,直到结束时,精神药物使用者的比例保持稳定在53%左右。美金刚发作前后的趋势有显着差异(p <0.001)。
结论:我们的结果表明,在这个大样本的老年患者中,美金刚发作与精神药物使用稳定之间存在时间关系。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录