Fractures are the most serious consequence of osteoporosis. Non-vertebral and non-hip fractures are seldom recognised as important, even though they account for the majority of all fractures. The most prevalent localisations are distal radius, proximal humerus, ribs, clavicle, and the pelvis. According to the results from large phase III clinical trials for placebo groups, their incidence ranges from 4.9 % to 12.0 %. Hospital morbidity data in Croatia in 2006 show that peripheral non-hip fractures ranked among the leading fifteen injuries, accounting for 23.7 % of all injuries in patients aged 60 years and above. Risk factors for non-hip and non-vertebral fractures are similar to other osteoporotic fractures, and the main are low bone mineral density and earlier fractures. Quality of life is considerably affected by these fractures, and medical costs are very high, soaring as high as 36.9% of all national medical costs in the USA. Non-vertebral non-hip fractures need more attention, which was also recognised by the European regulatory bodies that approve use of anti-osteoporotic drugs.

译文

:骨折是骨质疏松症最严重的后果。尽管非椎骨和非髋骨骨折占所有骨折的大部分,但很少被认为是重要的。最普遍的定位是radius骨远端,肱骨近端,肋骨,锁骨和骨盆。根据安慰剂组大型III期临床试验的结果,其发生率在4.9%至12.0%之间。 2006年克罗地亚的医院发病率数据显示,周围的非髋关节骨折在前15名患者中排名最高,占60岁及60岁以上患者受伤总数的23.7%。非髋关节和非椎骨骨折的危险因素与其他骨质疏松性骨折相似,主要是骨密度低和早期骨折。这些骨折严重影响了生活质量,医疗费用很高,高达美国所有国家医疗费用的36.9%。非椎骨非髋关节骨折需要引起更多关注,欧洲监管机构也认可使用抗骨质疏松药物。

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