Paratuberculosis or Johne's disease is a chronic enteritis of the cattle and other small ruminant animals caused by Mycobacterium avium subsp. paratuberculosis. In Argentina, the strains were characterized in beef and dairy cattle and deer in different genetic patterns by molecular tools. M. avium subsp. paratuberculosis has been linked in men to a chronic inflammation of the intestine, named Crohn's disease. There is clinical and experimental evidence to link M. avium subsp. paratuberculosis with Crohn's disease by PCR, positive bacteriological culture from mother milk, blood and affected tissues by in situ hybridization. The milk and sub-products might be one of the possible infection sources and it has been suggested that M. avium subsp. paratuberculosis could resist pasteurization. Several works showed that this mycobacteria could be present in retail milk of countries such as United Kingdom, USA, Czech Republic, and recently in Argentina. M. avium subsp. paratuberculosis was associated with different dairy products and water for human consumption. Therefore, it is possible that these food sources may have a role for transmission. New investigations should emphasize the role of contaminated food and water in human infection around the world and determine the possible zoonotic role of M. avium subsp. paratuberculosis.

译文

:肺结核或约翰氏病是由鸟分枝杆菌亚种引起的牛和其他小反刍动物的慢性肠炎。副结核病。在阿根廷,通过分子工具以不同的遗传模式对牛,奶牛和鹿中的菌株进行了鉴定。鸟分枝杆菌亚种副结核病在男性中与一种称为克罗恩氏病的肠道慢性炎症有关。有临床和实验证据将鸟分枝杆菌亚种联系起来。 PCR检测克罗恩病副结核病,通过原位杂交从母乳,血液和受影响的组织中进行阳性细菌培养。牛奶和副产品可能是可能的感染源之一,并且有人建议禽鸟支原体亚种。副结核病可以抵抗巴氏灭菌。几项研究表明,这种分枝杆菌可能存在于英国,美国,捷克共和国等国家的零售奶中,最近还出现在阿根廷。鸟分枝杆菌亚种副结核病与人类消费的各种乳制品和水有关。因此,这些食物来源可能具有传播的作用。新的调查应强调受污染的食物和水在全世界人类感染中的作用,并确定鸟分枝杆菌亚种可能的人畜共患病作用。副结核病。

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