Obesity and overweight are important risk factors for the development of diabetes mellitus type 2 and associated chronic diseases, and therefore, they have become serious global problems in the western and developed countries. But little is known about the neuroanatomical correlates of eating behavior and its influences on the central nervous processing in humans. We used functional magnetic resonance imaging (fMRI) to measure the cortical activation in 12 lean healthy humans during visual stimulation with food-related and nonfood pictures after a fasting period of at least 5 h. Compared to the nonfood pictures, the food stimuli elicited a significantly greater activity in the left orbitofrontal cortex and the insular/opercular cortex bilaterally with a stronger focus on the left side. Subjective ratings of appetite during the presentation of food-related stimuli modulated the activity in the insula bilaterally, the left operculum and the right putamen. These results provide further insights in the central nervous processing of food relevant stimuli in humans, specifically with respect to the subjective experience of appetite.

译文

:肥胖和超重是2型糖尿病和相关慢性疾病发展的重要危险因素,因此,它们已成为西方和发达国家严重的全球性问题。但是,人们对饮食行为的神经解剖学关联及其对人类中枢神经加工的影响知之甚少。我们使用功能性磁共振成像(fMRI)在禁食至少5小时后用食物相关图片和非食物图片进行视觉刺激期间,测量了12位瘦肉健康人的皮质激活。与非食物图片相比,食物刺激在左侧眶额叶皮层和双侧岛岛/腹膜皮层的活动明显增加,而对左侧的关注更大。在与食物有关的刺激过程中,主观的食欲评定调节了双侧岛,左left腹和右壳核的活动。这些结果提供了对人类食物相关刺激的中枢神经加工的进一步见解,特别是在食欲的主观感受方面。

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