Gender specific effects on human eating have been previously reported. Here we investigated sex-based differences in neural activation via whole-brain blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in response to high energy-dense (high-ED) vs. low-ED visual and auditory food cues in obese men vs. women in both fed and fasted states. The results show that in response to high vs. low ED foods in the fed state, obese men (vs. women) had greater activation in brain areas associated with motor control regions (e.g. supplementary motor areas) whereas women showed greater activation in cognitive-related regions. In the fasted state, obese men had greater activation in a visual-attention region whereas obese women showed greater activation in affective and reward related processing regions (e.g. caudate). Overall the results support our a priori hypothesis that obese women (vs. men) have greater neural activation in regions associated with cognition and emotion-related brain regions. These findings may improve our understanding of sex specific differences among obese individuals in eating behavior.

译文

:先前已经报道了性别对人类饮食的影响。在这里,我们通过对高能量密度(high-ED)与低ED视觉和听觉食物的反应,通过全脑血氧水平依赖性(BOLD)功能磁共振成像(fMRI)研究了神经激活中基于性别的差异在进食和禁食状态下,肥胖男性与女性的暗示。结果表明,在进食状态下,高ED和低ED食物相对应,肥胖男性(相对于女性)在与运动控制区域(例如,补充运动区域)相关的大脑区域具有更大的激活,而女性在认知-运动方面表现出更大的激活。相关区域。在禁食状态下,肥胖男性在视觉注意区域的激活程度更高,而肥胖女性在与情感和奖励相关的加工区域(例如尾状)的激活程度更高。总体而言,这些结果支持了我们的先验假设,即肥胖女性(相对于男性)在与认知和情绪相关的大脑区域相关的区域具有更大的神经激活作用。这些发现可能会增进我们对肥胖个体饮食行为之间性别差异的理解。

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