Acquired disorders of gesture imitation are amenable to treatment, but with poor generalisation toward gestures not included in the training program. We investigated the neural basis of this item-specific recovery in a patient with a slowly progressive posterior cortical atrophy, by means of an fMRI study comparing imitation of rehabilitated and not-rehabilitated gestures. Results suggested that in our patient gesture imitation recruited the mirror system and additional areas relevant to gesture analysis and preparation. Imitation of rehabilitated gestures activated the mirror neuron system, and also left dorsolateral prefrontal cortex and putamen, and the right anterior temporal cortex. This suggests that item-specific recovery was based on interaction of circuitry of imitation with neural systems involved in emotional and motivational processing.

译文

:获得性手势模仿障碍可以接受治疗,但对培训计划中未包括的手势的概括性较差。我们通过功能磁共振成像研究比较了康复姿势和未康复姿势的模仿,研究了缓慢进展的后皮质萎缩患者这一特定恢复的神经基础。结果表明,在我们的患者手势模仿中,招募了镜子系统以及与手势分析和准备有关的其他区域。复原手势的模仿激活了镜像神经元系统,还激活了左外侧前额叶皮层和壳核,以及右侧前颞叶皮层。这表明特定项目的恢复是基于模仿电路与涉及情绪和动机处理的神经系统的相互作用。

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