The chloroform-methanol extract of Euryops arabicus, collected from Saudi provenance, yielded a new kaurane diterpene (1) and seven methoxylated flavones (2-8), two of which are new (2 and 3). Structures of the compounds were elucidated through interpretation of spectral data of NMR, MS and comparison with literature values. All compounds were evaluated for their anti-tumor activities, employing four different cancer cell lines (WI-38, VERO, HepG2 and MCF-7), ABTS free radical scavenging and immunemodulatory effects. All metabolites had considerable antioxidant and immunestimulatory effects. All compounds showed anticancer activity with IC₅₀ in range 10-125 μM, whilst 2 and 6 showed significant anti-proliferative activity against HepG2 (IC₅₀ = 20 and 15 μM) and MCF-7 (IC₅₀ = 15 and 10 μM), respectively. This effect was attributed to significant S-phase cell cycle arrest.

译文

:从沙特阿拉伯产地采集的欧亚大陆的氯仿-甲醇提取物产生了一个新的月桂烷二萜(1)和七个甲氧基化的黄酮(2-8),其中两个是新的(2和3)。通过解释NMR,MS的光谱数据并与文献值进行比较来阐明化合物的结构。使用四种不同的癌细胞系(WI-38,VERO,HepG2和MCF-7),ABTS自由基清除和免疫调节作用,评估了所有化合物的抗肿瘤活性。所有代谢产物均具有相当大的抗氧化和免疫刺激作用。所有化合物均显示出抗癌活性,IC 50范围为10-125μM,而2和6分别显示出对HepG2(IC 50 = 20和15μM)和MCF-7(IC 50 = 15和10μM)的显着抗增殖活性。该作用归因于显着的S期细胞周期停滞。

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