OBJECTIVES:A recent report demonstrated that KLF6 IVS1 -27G>A substitution increases the transcription of alternatively spliced isoforms; this action was suggested to be associated with prostate cancer (pCA). To evaluate these findings among the Finnish population, a total of 3348 samples were analysed. METHODS:The variant was genotyped in 164 patients with familial pCA, 852 patients with unselected pCA, 459 patients with benign prostate hyperplasia (BPH), 923 male population controls, and 950 men from a Finnish prostate-specific antigen (PSA) screening trial with PSA levels less than 1.0ng/ml. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated by using logistic regression to estimate pCA risk. RESULTS:Association testing revealed no significant differences between familial prostate cancer patients and population controls (OR: 0.84; 95%CI, 0.56-1.28; p=0.42), unselected cases and controls (OR: 0.95; 95%CI, 0.76-1.19; p=0.63), or BPH cases and controls (OR: 1.12; 95%CI, 0.86-1.46; p=0.39). pCA and BPH cases were also compared with PSA-screened controls. None of these analyses revealed any significant associations. CONCLUSIONS:Our results do not support the suggested association of KLF6 IVS1 -27G>A germline polymorphism with pCA risk and also suggest that the variant is not a risk allele for BPH in the Finnish population.

译文

目的:最近的一份报告表明,KLF6 IVS1 -27G> A取代可增加其他剪接同工型的转录。提示该作用与前列腺癌(pCA)有关。为了评估芬兰人群中的这些发现,共分析了3348个样本。
方法:该变异体在164例家族性pCA患者,852例未选择pCA患者,459例良性前列腺增生症(BPH),923名男性人群对照和950名来自芬兰前列腺特异性抗原(PSA)筛查试验的男性中进行了基因分型。 PSA含量低于1.0ng / ml。通过使用逻辑回归估计pCA风险来计算赔率(OR)和相应的95%置信区间(95%CI)。
结果:关联测试显示家族性前列腺癌患者与人群对照(OR:0.84; 95%CI,0.56-1.28; p = 0.42),未选定病例和对照(OR:0.95; 95%CI,0.76-1.19)无显着差异; p = 0.63)或BPH病例和对照(OR:1.12; 95%CI,0.86-1.46; p = 0.39)。 pCA和BPH病例也与PSA筛查的对照进行了比较。这些分析均未显示任何重大关联。
结论:我们的结果不支持建议的KLF6 IVS1 -27G> A种系多态性与pCA风险的关联,也暗示该变异体不是芬兰人群BPH的风险等位基因。

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