Echovirus 11 (E-11) has been one of the most frequently discovered human enterovirus (HEV) in Finland during the past few years. We have studied molecular epidemiological patterns of E-11 from 1993 to 2007 exploiting the 257-nucleotide region in the 5'-part of the VP1 used for genetic typing of HEV. Designated genogroup D strains had a striking prevalence among the Finnish strains, a finding in accordance with the recent data from other geographical regions. The subgroup D4, harboring the oldest strains, had become extinct in the beginning of the millennium and D5 strains had taken over. Similarly, a new subgroup of D5 had started to diverge from the main D5 in 2006. However, in addition to endemic D strains, few single strains clustered also to genogroups A and C suggesting importation from more distant locations. The relatively large amino acid sequence variability between and within the genogroups favored the idea of antigenic differences. Neutralization assays confirmed that antigenic differences existed, although all studied E-11 strains were neutralized with antisera against the prototype strain Gregory. Five of the six studied strains belonging to genogroup D were, unexpectedly, also neutralized with antisera against coxsackievirus A9 Griggs.

译文

:Echovirus 11(E-11)在过去几年中一直是芬兰最常发现的人类肠道病毒(HEV)之一。我们已经研究了1993年至2007年E-11的分子流行病学模式,利用了用于HEV遗传分型的VP1 5'部分的257个核苷酸区域。指定的基因组D菌株在芬兰菌株中流行率很高,这一发现与其他地理区域的最新数据一致。拥有最古老菌株的D4亚组在千年初已灭绝,D5菌株已被接管。同样,D5的一个新亚组已于2006年开始与主要D5分离。但是,除了地方性D毒株外,几乎没有单个毒株也聚集到基因组A和C,提示从更远的地方输入。基因组之间和之内相对较大的氨基酸序列变异性支持抗原差异的想法。中和测定法确认存在抗原差异,尽管所有研究的E-11菌株均用针对原型菌株Gregory的抗血清中和。出乎意料的是,属于基因组D的六个研究菌株中的五个也被抗柯萨奇病毒A9 Griggs的抗血清中和。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录