The present study examined whether changes in the incidence of West syndrome (WS) could be used to evaluate changes in the quality of prenatal care over time. The incidence of WS in Finland did not change (1960-1991) in spite of increased survival of low-birth-weight infants. Small-for-gestational age (SGA) infants were more apt to develop infantile spasms than preterm average-for-gestational age infants. The number of SGA infants with neonatal hypoglycemia and infantile spasms decreased significantly. The number of cases of brain malformation and tuberous sclerosis increased; this probably reflects the development of more refined neuroradiological screening methods. Early prenatal factors seem to play a major role in the genesis of infantile spasms. Little can be done to reduce the incidence of WS, but every effort should be made to reduce the number of SGA infants by good prenatal care and treating neonatal hypoglycemia carefully.

译文

:本研究检查了西方综合症(WS)发病率的变化是否可用于评估随时间变化的产前护理质量。尽管低出生体重儿的存活率增加,但芬兰的WS发病率没有变化(1960-1991年)。小于胎龄儿(SGA)的婴儿比早产胎平均年龄的婴儿更容易发生婴儿痉挛。患有新生儿低血糖和婴儿痉挛症的SGA婴儿数量显着减少。脑畸形和结节性硬化症病例增加;这可能反映了更精细的神经放射学筛查方法的发展。早期的产前因素似乎在婴儿痉挛的发生中起主要作用。减少WS的发病率几乎无济于事,但应尽一切努力通过良好的产前护理并仔细治疗新生儿低血糖来减少SGA婴儿的数量。

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