In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw. In the analgesic test, AGT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection. However, AGT could not affect the NO level which induced by lambda-carrageenan. These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.

译文

:在本研究中,我们使用乙酸诱导的扭体反应模型和福尔马林试验研究了甘草绒毛(AGT)根的水提取物的镇痛作用,使用λ-模型研究了AGT的抗炎作用。角叉菜胶诱发的爪水肿。为了研究AGT的抗炎机制,我们检测了肝中谷胱甘肽过氧化物酶(GPx)和谷胱甘肽还原酶(GRx)的活性以及水肿爪中丙二醛(MDA)和NO的水平。在镇痛试验中,在福尔马林试验的后期,AGT(0.5和1.0 g / kg)减少了乙酸诱导的扭体反应和舔食时间。在抗炎试验中,AGT(0.5和1.0 g / kg)减少了λ-角叉菜胶给药后第三,第四,第五和第六小时的爪水肿,并增加了肝脏组织中SOD,GPx和GRx的活性并在注射λ-角叉菜胶后的第三小时降低了水肿爪中的MDA水平。然而,AGT不能影响由λ-角叉菜胶诱导的NO水平。这些结果表明,AGT具有镇痛和抗炎作用。 AGT的抗炎机制可能与通过增加肝脏中SOD,GPx和GRx的活性而降低水肿爪中MDA的水平有关。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录