A series of substituted xanthonyloxyacetic acids (5 and 6), 1,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-b]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.

译文

:一系列取代的氧杂蒽氧基氧乙酸(5和6),1,2-二氢呋喃[2,3-c]蒽酮-2-羧酸(7)和2,3-二氢呋喃[3,2-b]蒽酮-2合成了α-羧酸(8)并测试了大鼠的利尿和尿尿排尿活性。多数x吨-3-基氧基乙酸(5)和7显示出强效的利尿活性,而8种则具有较低的利尿活性。在5c,5f,5k,5m,5o,5p,5r,7m,7p和8q中发现了泌尿外科活动。

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