A novel withanolide glucoside, plantagiolide I (1), a new withanolide glucoside, plantagiolide J (2), and six known compounds (3-8) were isolated from the whole plant of Tacca plantaginea. Their structures were determined by spectroscopic and chemical methods. Compound 3 significantly inhibited tumor necrosis factor alpha (TNFα)-induced nuclear factor-kappaB (NF-κB) transcriptional activity in HepG2 cells in a dose-dependent manner, with IC(50) values of 9.0 µM. Compounds 1-8 enhanced the transcriptional activity of peroxisome proliferator-activated receptors (PPARs) in a dose-dependent manner, with EC(50) values ranging from 1.6 to 49.7 µM. In addition, the transactivational effects of compounds 1-8 on three individual PPAR subtypes, including PPARα, β(δ), and γ were evaluated. Compounds 1-8 significantly activated the transcriptional activity of PPARβ(δ), with EC(50) values in a ranging from 4.1 to 29.6 µM. These results provide scientific support for the use of T. plantaginea and its components for the prevention and treatment of inflammatory and metabolic diseases.

译文

:从塔克拉(Tacca plantaginea)的整个植物中分离出一种新的withanolide葡糖苷植物plant内酯I(1),一种新的withanolide葡糖苷,plantagiolide J(2)和六种已知化合物(3-8)。通过光谱和化学方法确定它们的结构。化合物3剂量依赖性地显着抑制HepG2细胞中肿瘤坏死因子α(TNFα)诱导的核因子-κB(NF-κB)转录活性,IC(50)值为9.0μM。化合物1-8以剂量依赖的方式增强了过氧化物酶体增殖物激活受体(PPAR)的转录活性,EC(50)值在1.6至49.7µM之间。另外,评价了化合物1-8对三种单独的PPAR亚型,包括PPARα,β(δ)和γ的反式激活作用。化合物1-8显着激活PPARβ(δ)的转录活性,EC(50)值在4.1至29.6µM之间。这些结果为植物假单胞菌及其成分用于炎性和代谢性疾病的预防和治疗提供了科学依据。

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