We report a case of prenatally diagnosed intracranial hemorrhage and hydrops in the fetus of a mother with a past history of surgical and medical treatment for gastric lymphoma and having high platelet counts thereafter. To the best of our knowledge, such a complication of maternal thrombocythemia has not been described in the literature. In our opinion, the possible pathophysiology of the disease is based on placental insufficiency due to infarctions and related fetal platelet dysfunction, leading to intracranial hemorrhage with subsequent hydrops fetalis. The trigger in this event appears to be trauma to the maternal abdomen. Certain measures for high-risk mothers such as avoidance of trauma to the abdomen and platelet-lowering medications like interferon-alpha may be useful for preventing such fetal complications.

译文

:我们报告了一例母亲的胎儿产前诊断为颅内出血和水肿的案例,该母亲过去有胃淋巴瘤的外科手术和药物治疗史,此后血小板计数很高。据我们所知,母体血小板增多症的这种并发症尚未在文献中描述。我们认为,该疾病的可能病理生理是基于梗死和相关的胎儿血小板功能障碍导致胎盘功能不全,从而导致颅内出血和随后的胎儿水肿。在这种情况下,触发因素似乎是孕妇腹部的创伤。对高危母亲采取某些措施,例如避免腹部创伤和降低干扰素-α等降低血小板的药物,对于预防此类胎儿并发症可能是有用的。

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